Malignant pleural mesothelioma with heterologous elements

被引：2

作者：

Kawai, Toshiaki ^{[1
]}

Seki, Reishi ^{[2
]}

Miyajima, Kuniharu ^{[3
]}

Nakashima, Hiroshi ^{[4
]}

Takeda, Takayuki ^{[5
]}

Murakami, Tomoyuki ^{[6
]}

Aoe, Keisuke ^{[7
,8
]}

Okabe, Kazunori ^{[7
,8
]}

Homma, Keiichi ^{[9
]}

Tsukamoto, Yoshitane ^{[10
]}

Sunada, Koichi ^{[11
]}

Terasaki, Yasuhiro ^{[12
]}

Iida, Maki ^{[13
]}

Orikasa, Hideki ^{[14
]}

Hiroshima, Kenzo ^{[15
]}

机构：

[1] Toda Cent Med Lab, Toda, Saitama, Japan

[2] Tokyo Saiseikai Cent Hosp, Dept Diagnost Pathol, Tokyo, Japan

[3] Niizashiki Cent Gen Hosp, Dept Thorac Surg & Oncol, Niiza, Japan

[4] Natl Def Med Coll, Dept Prevent Med & Publ Hlth, Tokorozawa, Saitama, Japan

[5] Uji Tokushukai Med Ctr, Div Resp Med, Uji, Kyoto, Japan

[6] Kanmon Med Ctr, Dept Pathol, Shimonoseki, Yamaguchi, Japan

[7] Yamaguchi Ube Med Ctr, Dept Med Oncol, Ube, Yamaguchi, Japan

[8] Yamaguchi Ube Med Ctr, Dept Thorac Surg, Ube, Yamaguchi, Japan

[9] Niigata Canc Ctr Hosp, Dept Pathol, Niigata, Japan

[10] Takarazuka City Hosp, Dept Pathol, Takarazuka, Hyogo, Japan

[11] Saiseikai Yokohamashi Tobu Hosp, Div Resp Med, Yokohama, Kanagawa, Japan

[12] Nippon Med Coll Hosp, Dept Analyt Human Pathol, Tokyo, Japan

[13] Yokosuka Gen Hosp Uwamachi, Dept Pathol, Yokosuka, Kanagawa, Japan

[14] Kawasaki Municipal Hosp, Dept Pathol, Kawasaki, Kanagawa, Japan

[15] Tokyo Womens Med Univ, Dept Pathol, Yachiyo Med Ctr, Yachiyo, Japan

来源：

JOURNAL OF CLINICAL PATHOLOGY | 2022年 / 75卷 / 10期

关键词：

pleura; immunohistochemistry; fish; EXTRASKELETAL OSTEOSARCOMA; SARCOMATOID MESOTHELIOMA; BAP1; IMMUNOHISTOCHEMISTRY; P16; FISH; DIAGNOSIS; MARKER; DIFFERENTIATION; CARCINOMA; CDKN2A; TUMOR;

D O I：

10.1136/jclinpath-2021-207575

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Aims Malignant pleural mesothelioma with heterologous elements (such as osseous, cartilaginous or rhabdomyoblastic differentiation) is very rare. We tried to differentiate such mesothelioma cases from extraskeletal pleural osteosarcoma, which is very challenging. Methods We compared 10 malignant pleural mesotheliomas (three biphasic and seven sarcomatoid types) with two pleural osteosarcomas using clinicopathological and immunohistochemical methods, and also fluorescence in situ hybridisation (FISH) to examine for homozygous deletion of p16. Results The median age was 72 years for mesotheliomas, and 69 years for osteosarcoma. For mesothelioma, eight cases were male and two were female. Growth was diffuse in all mesothelioma cases except case 10, where it was localised, as it was for the two osteosarcomas. Among mesothelioma cases, 80% displayed osteosarcomatous and 60% chondromatous elements, while 10% exhibited rhabdomyoblastic ones. Immunohistochemical labelling for calretinin and AE1/AE3 was present in 8/10 and 7/10 mesotheliomas, respectively, but in only one osteosarcoma. Loss of methylthioadenosine phosphorylase was seen in 5/7 mesotheliomas. FISH analysis revealed homozygous deletion of p16 in 5/8 mesothelioma and 2/2 osteosarcoma. Median survival was 6.5 months after biopsy or surgical operation in mesothelioma, and 12 months after operation in osteosarcoma. Conclusions Although median survival was longer for osteosarcoma than for malignant mesothelioma, we could not differentiate mesothelioma from pleural osteosarcoma on the combined basis of clinicopathological and immunohistochemical data, and FISH analysis. However, diffuse growth was more frequent in mesothelioma than in osteosarcoma.

引用

页码：690 / 695

页数：6

共 35 条

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