Alzheimer's Disease-Current Status and Future Directions

被引：30

作者：

Bhardwaj, Deepshikha ^{[1
]}

Mitra, Connie ^{[1
]}

Narasimhulu, Chandrakala Aluganti ^{[1
]}

Riad, Aladdin ^{[1
]}

Doomra, Mitsushita ^{[1
]}

Parthasarathy, Sampath ^{[1
]}

机构：

[1] Univ Cent Florida, Coll Med, Burnett Sch Biomed Sci, 6900 Lake Nona Blvd, Orlando, FL 32827 USA

来源：

JOURNAL OF MEDICINAL FOOD | 2017年 / 20卷 / 12期

关键词：

<bold>amyloid-beta plaques</bold>; <bold>amyloid precursor protein</bold>; <bold>apolipoprotein E</bold>; <bold>neurofibrillary tangles</bold>; <bold>neuroimaging</bold>; <bold>nutrition</bold>; DENSITY-LIPOPROTEIN RECEPTOR; GLYCATION END-PRODUCTS; MILD COGNITIVE IMPAIRMENT; AMYLOID PRECURSOR PROTEIN; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; ALCOHOL-CONSUMPTION; MEDITERRANEAN DIET; APOLIPOPROTEIN-E;

D O I：

10.1089/jmf.2017.0093

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Alzheimer's disease (AD) is an age-related neurodegenerative disorder of the brain. The presence of amyloid-beta (A) plaques, neurofibrillary tangles (NFTs), loss of neurons, synapses, and altered sensory perceptions, including memory loss, delineate AD. However, the cause of AD is not clearly known. Several genetic and nongenetic factors have been implicated in the disease. Of the genes, the 4 allele of apolipoprotein E is the largest known genetic risk factor of AD. This review article focuses on the various genetic and other predisposing factors that account for AD, pathophysiology of the disease, and the mechanisms by which A plaques and NFTs are formed and could affect AD brain. In addition, recent advances and current diagnostics available for AD patients are detailed. As oxidative stress has been implicated in the etiology of the disease, special emphasis is given for nutrition based antioxidant therapies and interventional strategies for reducing/treating AD.

引用

页码：1141 / 1151

页数：11

共 103 条

[21] Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease [J].

Dawkins, Edgar ;

Small, David H. .

JOURNAL OF NEUROCHEMISTRY, 2014, 129 (05) :756-769

[22] Cardiovascular risk factors and future risk of Alzheimer's disease [J].

de Bruijn, Renee F. A. G. ;

Ikram, M. Arfan .

BMC MEDICINE, 2014, 12

[23] Type 3 diabetes is sporadic Alzheimer's disease: Mini-review [J].

de la Monte, Suzanne M. .

EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2014, 24 (12) :1954-1960

[24] Alzheimer Presenilin-1 Mutations Dramatically Reduce Trimming of Long Amyloid β-Peptides (Aβ) by γ-Secretase to Increase 42-to-40-Residue Aβ [J].

Fernandez, Marty A. ;

Klutkowski, Julia A. ;

Freret, Taylor ;

Wolfe, Michael S. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (45) :31043-31052

[25] The role of dietary coconut for the prevention and treatment of Alzheimer's disease: potential mechanisms of action [J].

Fernando, W. M. A. D. B. ;

Martins, Ian J. ;

Goozee, K. G. ;

Brennan, Charles S. ;

Jayasena, V. ;

Martins, R. N. .

BRITISH JOURNAL OF NUTRITION, 2015, 114 (01) :1-14

[26] Cerebrovascular lesions induce transient β-amyloid deposition [J].

Garcia-Alloza, Monica ;

Gregory, Julia ;

Kuchibhotla, Kishore V. ;

Fine, Sara ;

Wei, Ying ;

Ayata, Cenk ;

Frosch, Matthew P. ;

Greenberg, Steven M. ;

Bacskai, Brian J. .

BRAIN, 2011, 134 :3694-3704

[27] Review: magnetic resonance imaging of male/female differences in human adolescent brain anatomy [J].

Giedd, Jay N. ;

Raznahan, Armin ;

Mills, Kathryn L. ;

Lenroot, Rhoshel K. .

BIOLOGY OF SEX DIFFERENCES, 2012, 3

[28] Celastrus paniculatus seed water soluble extracts protect cultured rat forebrain neuronal cells from hydrogen peroxide-induced oxidative injury [J].

Godkar, P ;

Gordon, RK ;

Ravindran, A ;

Doctor, BP .

FITOTERAPIA, 2003, 74 (7-8) :658-669

[29] Moments of joy and delight: the meaning of traditional food in dementia care [J].

Hanssen, Ingrid ;

Kuven, Britt Moene .

JOURNAL OF CLINICAL NURSING, 2016, 25 (5-6) :866-874

[30] Proton MR spectroscopic study at 3 Tesla or glutamate/glutamine in Alzheimer's disease [J].

Hattori, N ;

Abe, K ;

Sakoda, S ;

Sawada, T .

NEUROREPORT, 2002, 13 (01) :183-186

← 1 2 3 4 5 6 7 8 9 10 →