Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo

被引：5
|
作者：
An, Lijun [1 ,2 ]
Ma, Jun [1 ,2 ]
Yang, Xueyuan [1 ,2 ]
Liang, Yue [1 ,2 ]
Wang, Huimei [1 ,2 ]
Tuerhong, Muhetaer [3 ]
Lall, Namrita [4 ]
Abudukeremu, Munira [3 ]
Zhang, Yi [5 ,6 ]
Lee, Dongho [7 ]
Xu, Jing [1 ,2 ,8 ]
Wu, Xiaohui [9 ]
Guo, Yuanqiang [1 ,2 ]
机构：
[1] Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Tianjin 300350, Peoples R China
[2] Nankai Univ, Tianjin Key Lab Mol Drug Res, Tianjin 300350, Peoples R China
[3] Kashgar Univ, Coll Chem & Environm Sci, Kashgar 844000, Peoples R China
[4] Univ Pretoria, Dept Plant & Soil Sci, ZA-0002 Pretoria, South Africa
[5] Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin Key Lab TCM Chem & Anal, Tianjin 300193, Peoples R China
[6] Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin 300193, Peoples R China
[7] Korea Univ, Coll Life Sci & Biotechnol, Seoul 02841, South Korea
[8] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
[9] Tianjin Med Univ, Coll Pharm, Tianjin 300070, Peoples R China
来源：
BIOORGANIC CHEMISTRY | 2020年 / 98卷
基金：
中国国家自然科学基金;
关键词：
Homotriterpenoid; Anti-inflammation; Zebrafish model; Molecular docking; Casearia kurzii; CYTOTOXIC CLERODANE DITERPENOIDS; LEAVES; SYLVESTRIS; TRITERPENOIDS; DERIVATIVES; INHIBITOR; GLYCOSIDE; TWIGS; BARK;
D O I：
10.1016/j.bioorg.2020.103758
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Caseahomopene A (1), a rare natural product with a ring-expanded homotriterpenoid skeleton, was isolated from the leaves of Casearia kurzii. The structure including the absolute configuration was determined by spectroscopic data and X-ray crystallography analysis. Compound 1 showed anti-inflammatory effects in vitro and in vivo using LPS-stimulated cell and zebrafish model. As a potential anti-inflammatory agent, the anti-inflammatory mechanism of 1 was also investigated.
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页数：7
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