Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo

被引：5

作者：

An, Lijun ^{[1
,2
]}

Ma, Jun ^{[1
,2
]}

Yang, Xueyuan ^{[1
,2
]}

Liang, Yue ^{[1
,2
]}

Wang, Huimei ^{[1
,2
]}

Tuerhong, Muhetaer ^{[3
]}

Lall, Namrita ^{[4
]}

Abudukeremu, Munira ^{[3
]}

Zhang, Yi ^{[5
,6
]}

Lee, Dongho ^{[7
]}

Xu, Jing ^{[1
,2
,8
]}

Wu, Xiaohui ^{[9
]}

Guo, Yuanqiang ^{[1
,2
]}

机构：

[1] Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Tianjin 300350, Peoples R China

[2] Nankai Univ, Tianjin Key Lab Mol Drug Res, Tianjin 300350, Peoples R China

[3] Kashgar Univ, Coll Chem & Environm Sci, Kashgar 844000, Peoples R China

[4] Univ Pretoria, Dept Plant & Soil Sci, ZA-0002 Pretoria, South Africa

[5] Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin Key Lab TCM Chem & Anal, Tianjin 300193, Peoples R China

[6] Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin 300193, Peoples R China

[7] Korea Univ, Coll Life Sci & Biotechnol, Seoul 02841, South Korea

[8] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[9] Tianjin Med Univ, Coll Pharm, Tianjin 300070, Peoples R China

来源：

BIOORGANIC CHEMISTRY | 2020年 / 98卷

基金：

中国国家自然科学基金;

关键词：

Homotriterpenoid; Anti-inflammation; Zebrafish model; Molecular docking; Casearia kurzii; CYTOTOXIC CLERODANE DITERPENOIDS; LEAVES; SYLVESTRIS; TRITERPENOIDS; DERIVATIVES; INHIBITOR; GLYCOSIDE; TWIGS; BARK;

D O I：

10.1016/j.bioorg.2020.103758

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Caseahomopene A (1), a rare natural product with a ring-expanded homotriterpenoid skeleton, was isolated from the leaves of Casearia kurzii. The structure including the absolute configuration was determined by spectroscopic data and X-ray crystallography analysis. Compound 1 showed anti-inflammatory effects in vitro and in vivo using LPS-stimulated cell and zebrafish model. As a potential anti-inflammatory agent, the anti-inflammatory mechanism of 1 was also investigated.

引用

页数：7

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