Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivo

被引：5

作者：

An, Lijun ^{[1
,2
]}

Ma, Jun ^{[1
,2
]}

Yang, Xueyuan ^{[1
,2
]}

Liang, Yue ^{[1
,2
]}

Wang, Huimei ^{[1
,2
]}

Tuerhong, Muhetaer ^{[3
]}

Lall, Namrita ^{[4
]}

Abudukeremu, Munira ^{[3
]}

Zhang, Yi ^{[5
,6
]}

Lee, Dongho ^{[7
]}

Xu, Jing ^{[1
,2
,8
]}

Wu, Xiaohui ^{[9
]}

Guo, Yuanqiang ^{[1
,2
]}

机构：

[1] Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Tianjin 300350, Peoples R China

[2] Nankai Univ, Tianjin Key Lab Mol Drug Res, Tianjin 300350, Peoples R China

[3] Kashgar Univ, Coll Chem & Environm Sci, Kashgar 844000, Peoples R China

[4] Univ Pretoria, Dept Plant & Soil Sci, ZA-0002 Pretoria, South Africa

[5] Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin Key Lab TCM Chem & Anal, Tianjin 300193, Peoples R China

[6] Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin 300193, Peoples R China

[7] Korea Univ, Coll Life Sci & Biotechnol, Seoul 02841, South Korea

[8] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[9] Tianjin Med Univ, Coll Pharm, Tianjin 300070, Peoples R China

来源：

BIOORGANIC CHEMISTRY | 2020年 / 98卷

基金：

中国国家自然科学基金;

关键词：

Homotriterpenoid; Anti-inflammation; Zebrafish model; Molecular docking; Casearia kurzii; CYTOTOXIC CLERODANE DITERPENOIDS; LEAVES; SYLVESTRIS; TRITERPENOIDS; DERIVATIVES; INHIBITOR; GLYCOSIDE; TWIGS; BARK;

D O I：

10.1016/j.bioorg.2020.103758

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Caseahomopene A (1), a rare natural product with a ring-expanded homotriterpenoid skeleton, was isolated from the leaves of Casearia kurzii. The structure including the absolute configuration was determined by spectroscopic data and X-ray crystallography analysis. Compound 1 showed anti-inflammatory effects in vitro and in vivo using LPS-stimulated cell and zebrafish model. As a potential anti-inflammatory agent, the anti-inflammatory mechanism of 1 was also investigated.

引用

页数：7

共 50 条

[1] Bioactive triterpenoids from Lantana camara showing anti-inflammatory activities in vitro and in vivo
Wu, Peng
Song, Ziteng
Wang, Xuelian
Li, Ying
Li, Yuhao
Cui, Jianlin
Tuerhong, Muhetaer
Jin, Da-Qing
Abudukeremu, Munira
Lee, Dongho
Xu, Jing
Guo, Yuanqiang
BIOORGANIC CHEMISTRY, 2020, 101
[2] Natural iridoids from Patrinia heterophylla showing anti-inflammatory activities in vitro and in vivo
Wu, Peng
Song, Ziteng
Li, Ying
Wang, Huimei
Zhang, Han
Bao, Jiahe
Li, Yuhao
Cui, Jianlin
Jin, Da-Qing
Wang, Aijie
Liang, Bin
Lee, Dongho
Xu, Jing
Guo, Yuanqiang
BIOORGANIC CHEMISTRY, 2020, 104
[3] In vivo and in vitro anti-inflammatory activities of neoandrographolide
Liu, Jun
Wang, Zheng-Tao
Ji, Li-Li
AMERICAN JOURNAL OF CHINESE MEDICINE, 2007, 35 (02): : 317 - 328
[4] Anti-Inflammatory Activities of Leaf Oil from Cinnamomum subavenium In Vitro and In Vivo
Hao, Xincai
Sun, Weiguang
Ke, Changbin
Wang, Fuqian
Xue, Yongbo
Luo, Zengwei
Wang, Xuanbin
Zhang, Jinwen
Zhang, Yonghui
BIOMED RESEARCH INTERNATIONAL, 2019, 2019
[5] Chemical constituents from Alismatis Rhizoma and their anti-inflammatory activities in vitro and in vivo
Liu, Shan-shan
Sheng, Wen-long
Li, Yun
Zhang, Shan-shan
Zhu, Jing-jing
Gao, Hui-min
Yan, Li-hua
Wang, Zhi-min
Gao, Lu
Zhang, Mei
BIOORGANIC CHEMISTRY, 2019, 92
[6] In vivo Anti-inflammatory and in vitro Antioxidant Activities of Peperomia pellucida
Mutee, A. F.
Salhimi, S. M.
Yam, M. F.
Lim, C. P.
Abdullah, G. Z.
Ameer, O. Z.
Abdulkarim, M. F.
Asmawi, M. Z.
INTERNATIONAL JOURNAL OF PHARMACOLOGY, 2010, 6 (05) : 686 - 690
[7] In Vitro Antioxidant and In Vivo Anti-Inflammatory Activities of Ophioglossum thermale
Zhang, Xue-Qiong
Kim, Jin-Hwa
Lee, Geun-Soo
Pyo, Hyeong-Bae
Shin, Eun-Young
Kim, Eung-Gook
Zhang, Yong-He
AMERICAN JOURNAL OF CHINESE MEDICINE, 2012, 40 (02): : 279 - 293
[8] Anti-Inflammatory Activities of Cinnamomum cassia Constituents In Vitro and In Vivo
Liao, Jung-Chun
Deng, Jeng-Shyan
Chiu, Chuan-Sung
Hou, Wen-Chi
Huang, Shyh-Shyun
Shie, Pei-Hsin
Huang, Guang-Jhong
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2012, 2012
[9] Anti-Osteoarthritic and Anti-Inflammatory Activities of Diazine: In Vitro and In Vivo Studies
Gui, Binjie
Zhang, Jinling
Wang, Sisheng
Rong, Genxiang
MEDICAL SCIENCE MONITOR, 2018, 24 : 76 - 83
[10] In vivo and in vitro anti-inflammatory and anti-nociceptive activities of lovastatin in rodents
Goncalves, D. O.
Calou, I. B. F.
Siqueira, R. P.
Lopes, A. A.
Leal, L. K. A.
Brito, G. A. C.
Tome, A. R.
Viana, G. S. B.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2011, 44 (02) : 173 - 181

← 1 2 3 4 5 →