The Trypanosoma cruzi proteome

被引：322

作者：

Atwood, JA

Weatherly, DB

Minning, TA

Bundy, B

Cavola, C

Opperdoes, FR

Orlando, R

Tarleton, RL ^{[1
]}

机构：

[1] Univ Georgia, Ctr Trop & Emerging Global Dis, Athens, GA 30602 USA

[2] Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA

[3] Univ Georgia, Dept Cellular Biol, Athens, GA 30602 USA

[4] Catholic Univ Louvain, Brussels, Belgium

[5] Christian de Duve Inst Cellular Pathol, Trop Dis Res Unit, Brussels, Belgium

[6] Christian de Duve Inst Cellular Pathol, Biochem Lab, Brussels, Belgium

来源：

SCIENCE | 2005年 / 309卷 / 5733期

关键词：

D O I：

10.1126/science.1110289

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To complement the sequencing of the three kinetoplastid genomes reported in this issue, we have undertaken a whole-organism, proteomic analysis of the four life-cycle stages of Trypanosoma cruzi. Peptides mapping to 2784 proteins in 1168 protein groups from the annotated T. cruzi genome were identified across the four life-cycte stages. Protein products were identified from >1000 genes annotated as "hypothetical" in the sequenced genome, including members of a newly defined gene family annotated, as mucin-associated surface proteins. The four parasite stages appear to use distinct energy sources, including histidine for stages present in the insect vectors and fatty acids by intracellular amastigotes.

引用

页码：473 / 476

页数：4

共 24 条

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