Caspase-3 inhibition blocks long-term potentiation in hippocampal slices

被引:0
作者
Kudryashov, IE [1 ]
Yakovlev, AA [1 ]
Kudryashova, IV [1 ]
Gulyaeva, NV [1 ]
机构
[1] Russian Acad Sci, Inst Higher Nervous Act & Neurophysiol, Moscow 117865, Russia
关键词
long-term potentiation; hippocampus; CA1; caspase-3; Z-DEVD-FMK;
D O I
暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Incubation of hippocampal slices with Z-DEVD-FMK, a specific inhibitor of caspase-3, elicits a time dependent decrease in long-term potentiation (LTP). After 4 hours or later after the incubation with Z-DEVD-FMK the tetanization fails to induce LTP. However, Z-DEVD-FMK does not affect basal indices of synaptic plasticity and short-term plasticity (population spike amplitudes and paired pulse facititation). The results are the first evidence for the involvement of caspase-3-mediated mechanisms in long-term potentiation phenomenon.
引用
收藏
页码:537 / 540
页数:4
相关论文
共 12 条
[1]  
Chan SL, 1999, J NEUROSCI RES, V58, P167, DOI 10.1002/(SICI)1097-4547(19991001)58:1<167::AID-JNR16>3.3.CO
[2]  
2-B
[3]   EVIDENCE THAT PROTEIN KINASE-M DOES NOT MAINTAIN LONG-TERM POTENTIATION [J].
DENNY, JB ;
POLANCURTAIN, J ;
RODRIGUEZ, S ;
WAYNER, MJ ;
ARMSTRONG, DL .
BRAIN RESEARCH, 1990, 534 (1-2) :201-208
[4]   Mammalian caspases: Structure, activation, substrates, and functions during apoptosis [J].
Earnshaw, WC ;
Martins, LM ;
Kaufmann, SH .
ANNUAL REVIEW OF BIOCHEMISTRY, 1999, 68 :383-424
[5]   Specific proteolysis of the NR2 subunit at multiple sites by calpain [J].
Guttmann, RP ;
Baker, DL ;
Seifert, KM ;
Cohen, AS ;
Coulter, DA ;
Lynch, DR .
JOURNAL OF NEUROCHEMISTRY, 2001, 78 (05) :1083-1093
[6]  
Hölscher C, 1999, J NEUROSCI RES, V58, P62
[7]   Activation of calcium/calmodulin-dependent protein kinase IV in long term potentiation in the rat hippocampal CA1 region [J].
Kasahara, J ;
Fukunaga, K ;
Miyamoto, E .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (26) :24044-24050
[8]   Caspases cleave the amino-terminal calpain inhibitory unit of calpastatin during apoptosis in human Jurkat T cells [J].
Kato, M ;
Nonaka, T ;
Maki, M ;
Kikuchi, H ;
Imajoh-Ohmi, S .
JOURNAL OF BIOCHEMISTRY, 2000, 127 (02) :297-305
[9]   Periods of postnatal maturation of hippocampus: synaptic modifications and neuronal disconnection [J].
Kudryashov, IE ;
Onufriev, MV ;
Kudryashova, IV ;
Gulyaeva, NV .
DEVELOPMENTAL BRAIN RESEARCH, 2001, 132 (02) :113-120
[10]   AN ESSENTIAL ROLE FOR POSTSYNAPTIC CALMODULIN AND PROTEIN-KINASE ACTIVITY IN LONG-TERM POTENTIATION [J].
MALENKA, RC ;
KAUER, JA ;
PERKEL, DJ ;
MAUK, MD ;
KELLY, PT ;
NICOLL, RA ;
WAXHAM, MN .
NATURE, 1989, 340 (6234) :554-557