Caspase-3 inhibition blocks long-term potentiation in hippocampal slices

被引：0

作者：

Kudryashov, IE ^{[1
]}

Yakovlev, AA ^{[1
]}

Kudryashova, IV ^{[1
]}

Gulyaeva, NV ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Higher Nervous Act & Neurophysiol, Moscow 117865, Russia

来源：

ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA | 2003年 / 53卷 / 05期

关键词：

long-term potentiation; hippocampus; CA1; caspase-3; Z-DEVD-FMK;

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Incubation of hippocampal slices with Z-DEVD-FMK, a specific inhibitor of caspase-3, elicits a time dependent decrease in long-term potentiation (LTP). After 4 hours or later after the incubation with Z-DEVD-FMK the tetanization fails to induce LTP. However, Z-DEVD-FMK does not affect basal indices of synaptic plasticity and short-term plasticity (population spike amplitudes and paired pulse facititation). The results are the first evidence for the involvement of caspase-3-mediated mechanisms in long-term potentiation phenomenon.

引用

页码：537 / 540

页数：4

共 12 条

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