Positive selection of CD4(+) and CD8(+) T cells

被引：50
作者：
Guidos, CJ
机构：
[1] Division of Immunology and Cancer, Hosp. for Sick Children Res. Inst., Toronto, Ont. M5G 1X8
来源：
CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 02期
关键词：
D O I：
10.1016/S0952-7915(96)80061-6
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Significant progress has been made in characterizing intermediates and defining individual steps of positive selection, providing important insights into mechanisms of CD4/CD8 lineage commitment. New evidence suggests that specific recognition of peptides may be important for positive selection of CD4+ T cells. Several studies have defined signal-transduction pathways important for positive selection and have provided evidence that distinct signaling pathways may regulate positive versus negative selection.
引用
收藏
页码：225 / 232
页数：8
相关论文
共 53 条
[1]   SELECTIVE REQUIREMENT FOR MAP KINASE ACTIVATION IN THYMOCYTE DIFFERENTIATION [J].
ALBEROLAILA, J ;
FORBUSH, KA ;
SEGER, R ;
KREBS, EG ;
PERLMUTTER, RM .
NATURE, 1995, 373 (6515) :620-623
[2]  
ANDERSON G, 1995, J IMMUNOL, V154, P3636
[3]   INVOLVEMENT OF THE PROTEIN-TYROSINE KINASE P56(LCK) IN T-CELL SIGNALING AND THYMOCYTE DEVELOPMENT [J].
ANDERSON, SJ ;
LEVIN, SD ;
PERLMUTTER, RM .
ADVANCES IN IMMUNOLOGY, VOLUME 56, 1994, 56 :151-178
[4]   DEFECTIVE T-CELL RECEPTOR SIGNALING AND CD8(+) THYMIC SELECTION IN HUMANS LACKING ZAP-70 KINASE [J].
ARPAIA, E ;
SHAHAR, M ;
DADI, H ;
COHEN, A ;
ROIFMAN, CM .
CELL, 1994, 76 (05) :947-958
[5]   POSITIVE SELECTION OF MOUSE NK1(+) T-CELLS BY CD1-EXPRESSING CORTICAL THYMOCYTES [J].
BENDELAC, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (06) :2091-2096
[6]   CD1 RECOGNITION BY MOUSE NK1(+) T-LYMPHOCYTES [J].
BENDELAC, A ;
LANTZ, O ;
QUIMBY, ME ;
YEWDELL, JW ;
BENNINK, JR ;
BRUTKIEWICZ, RR .
SCIENCE, 1995, 268 (5212) :863-865
[7]   EXCLUSION AND INCLUSION OF ALPHA-T-CELL AND BETA-T-CELL RECEPTOR ALLELES [J].
BORGULYA, P ;
KISHI, H ;
UEMATSU, Y ;
VONBOEHMER, H .
CELL, 1992, 69 (03) :529-537
[8]   TAP-INDEPENDENT, BETA(2)-MICROGLOBULIN-DEPENDENT SURFACE EXPRESSION OF FUNCTIONAL-MOUSE CD1.1 [J].
BRUTKIEWICZ, RR ;
BENNINK, JR ;
YEWDELL, JW ;
BENDELAC, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (06) :1913-1919
[9]   ZAP-70 DEFICIENCY IN AN AUTOSOMAL RECESSIVE FORM OF SEVERE COMBINED IMMUNODEFICIENCY [J].
CHAN, AC ;
KADLECEK, TA ;
ELDER, ME ;
FILIPOVICH, AH ;
KUO, WL ;
IWASHIMA, M ;
PARSLOW, TG ;
WEISS, A .
SCIENCE, 1994, 264 (5165) :1599-1601
[10]   ROLE OF CORECEPTORS IN POSITIVE SELECTION AND LINEAGE COMMITMENT [J].
CHAN, SH ;
WALTZINGER, C ;
BARON, A ;
BENOIST, C ;
MATHIS, D .
EMBO JOURNAL, 1994, 13 (19) :4482-4489
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