The Role of Childhood Asthma in Obesity Development A Nationwide US Multicohort Study

被引：12

作者：

Stratakis, Nikos ^{[1
]}

Garcia, Erika ^{[1
]}

Chandran, Aruna ^{[2
]}

Hsu, Tingju ^{[2
]}

Alshawabkeh, Akram ^{[3
]}

Aris, Izzuddin M. ^{[4
,5
]}

Aschner, Judy L. ^{[6
,7
]}

Breton, Carrie ^{[1
]}

Burbank, Allison ^{[8
]}

Camargo, Carlos A. Jr Jr ^{[9
]}

Carroll, Kecia N. ^{[10
]}

Chen, Zhanghua ^{[1
]}

Claud, Erika C. ^{[11
,12
]}

Dabelea, Dana ^{[13
]}

Dunlop, Anne L. ^{[14
,15
]}

Elliott, Amy J. ^{[16
]}

Ferrara, Assiamira ^{[17
]}

Ganiban, Jody M. ^{[18
]}

Gern, James E. ^{[19
]}

Gold, Diane R. ^{[20
,21
,22
]}

Gower, William A. ^{[8
]}

Hertz-Picciotto, Irva ^{[23
]}

Karagas, Margaret R. ^{[24
]}

Karr, Catherine J. ^{[25
]}

Lester, Barry ^{[26
,27
,28
]}

Leve, Leslie D. ^{[29
]}

Litonjua, Augusto A. ^{[30
]}

Ludena, Yunin ^{[23
]}

McEvoy, Cindy T. ^{[31
]}

Miller, Rachel L. ^{[32
]}

Mueller, Noel T. ^{[2
]}

O'Connor, Thomas G. ^{[33
,34
,35
,36
]}

Oken, Emily ^{[4
,5
]}

O'Shea, T. Michael ^{[8
]}

Perera, Frederica ^{[37
]}

Stanford, Joseph B. ^{[38
]}

Rivera-Spoljaric, Katherine ^{[39
]}

Rundle, Andrew ^{[37
]}

Trasande, Leonardo ^{[40
,41
,42
]}

Wright, Rosalind J. ^{[43
]}

Zhang, Yue ^{[44
]}

Zhu, Yeyi ^{[17
]}

Berhane, Kiros ^{[45
]}

Gilliland, Frank ^{[1
]}

Chatzi, Lida ^{[1
]}

机构：

[1] Univ Southern Calif, Dept Prevent Med, Los Angeles, CA 90089 USA

[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[3] Northeastern Univ, Dept Civil & Environm Engn, Boston, MA 02115 USA

[4] Harvard Med Sch, Dept Populat Med, Boston, MA 02115 USA

[5] Harvard Pilgrim Hlth Care Inst, Boston, MA USA

[6] Hackensack Meridian Sch Med, Dept Pediat, Nutley, NJ USA

[7] Albert Einstein Coll Med, Bronx, NY 10467 USA

[8] Univ N Carolina, Sch Med, Dept Pediat, Chapel Hill, NC USA

[9] Harvard Med Sch, Dept Emergency Med, Massachusetts Gen Hosp, Boston, MA 02115 USA

[10] Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN 37232 USA

[11] Univ Chicago, Dept Pediat, Chicago, IL 60637 USA

[12] Univ Chicago, Dept Med, 5841 S Maryland Ave, Chicago, IL 60637 USA

[13] Univ Colorado, Anschutz Med Campus, Aurora, CO USA

[14] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA 30322 USA

[15] Emory Univ, Dept Family & Prevent Med, Atlanta, GA 30322 USA

[16] Avera Res Inst, Sioux Falls, SD USA

[17] Kaiser Permanente Northern Calif Div Res, Oakland, CA USA

[18] George Washington Univ, Dept Psychol, Washington, DC 20052 USA

[19] Univ Wisconsin, Dept Pediat, Sch Med & Publ Hlth, Madison, WI USA

[20] Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA

[21] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA

[22] Harvard Med Sch, Boston, MA 02115 USA

[23] Univ Calif Davis, Sch Med, Davis, CA 95616 USA

[24] Dartmouth Coll, Geisel Sch Med, Hanover, NH 03755 USA

[25] Univ Washington, Dept Pediat & Environm & Occupat Hlth Sci, Seattle, WA 98195 USA

[26] Brown Alpert Med Sch, Dept Psychiat & Human Behav, Providence, RI USA

[27] Brown Alpert Med Sch, Dept Pediat, Providence, RI USA

[28] Women & Infants Hosp Rhode Isl, Providence, RI USA

[29] Univ Oregon, Dept Educ, Eugene, OR 97403 USA

[30] Univ Rochester, Med Ctr, Dept Pediat, Div Pediat Pulm Med, Rochester, NY 14642 USA

[31] Oregon Hlth & Sci Univ, Dept Pediat, 3181 Sw Sam Jackson Pk Rd, Portland, OR 97201 USA

[32] Icahn Sch Med Mt Sinai, Div Clin Immunol, Dept Med, New York, NY 10029 USA

[33] Univ Rochester, Dept Psychiat, Rochester, NY USA

[34] Univ Rochester, Dept Psychol, Meliora Hall, Rochester, NY 14627 USA

[35] Univ Rochester, Dept Neurosci, Rochester, NY USA

[36] Univ Rochester, Dept Obstet & Gynecol, Rochester, NY USA

[37] Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, New York, NY USA

[38] Univ Utah, Dept Family & Prevent Med, Salt Lake City, UT USA

[39] Washington Univ, Sch Med, Dept Pediat, Div Allergy Immunol & Pulm Med,St Louis Childrens, St Louis, MO 63110 USA

[40] NYU, Sch Med, Dept Pediat, New York, NY USA

[41] NYU, Sch Med, Dept Environm Med, New York, NY USA

[42] NYU, Sch Med, Dept Populat Hlth, New York, NY USA

[43] Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA

[44] Univ Utah, Dept Internal Med, Salt Lake City, UT 84112 USA

[45] Columbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY USA

来源：

EPIDEMIOLOGY | 2022年 / 33卷 / 01期

基金：

美国国家卫生研究院;

关键词：

asthma; obesity; childhood; asthma medication; ECHO; INCREASES ENERGY-EXPENDITURE; MEDICATION USE; CHILDREN; QUESTIONNAIRE; STIMULATION; DISPARITIES; MEDIATION; COMMUNITY; DIAGNOSIS; AGONIST;

D O I：

10.1097/EDE.0000000000001421

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Rationale: Asthma and obesity often co-occur. It has been hypothesized that asthma may contribute to childhood obesity onset. Objectives: To determine if childhood asthma is associated with incident obesity and examine the role of asthma medication in this association. Methods: We studied 8,716 children between ages 6 and 18.5 years who were nonobese at study entry participating in 18 US cohorts of the Environmental influences on Child Health Outcomes program (among 7,299 children with complete covariate data mean [SD] study entry age = 7.2 [1.6] years and follow up = 5.3 [3.1] years). Measurements and Main Results: We defined asthma based on caregiver report of provider diagnosis. Incident obesity was defined as the first documented body mass index >= 95th percentile for age and sex following asthma status ascertainment. Over the study period, 26% of children had an asthma diagnosis and 11% developed obesity. Cox proportional hazards models with sex-specific baseline hazards were fitted to assess the association of asthma diagnosis with obesity incidence. Children with asthma had a 23% (95% confidence intervals [CI] = 4, 44) higher risk for subsequently developing obesity compared with those without asthma. A novel mediation analysis was also conducted to decompose the total asthma effect on obesity into pathways mediated and not mediated by asthma medication use. Use of asthma medication attenuated the total estimated effect of asthma on obesity by 64% (excess hazard ratios = 0.64; 95% CI = -1.05, -0.23). Conclusions: This nationwide study supports the hypothesis that childhood asthma is associated with later risk of obesity. Asthma medication may reduce this association and merits further investigation as a potential strategy for obesity prevention among children with asthma.

引用

页码：131 / 140

页数：10

共 43 条

[1] ACUTE EFFECTS OF INHALED SALBUTAMOL ON THE METABOLIC-RATE OF NORMAL SUBJECTS [J].

AMOROSO, P ;

WILSON, SR ;

MOXHAM, J ;

PONTE, J .

THORAX, 1993, 48 (09) :882-885

[2] ADIPOCYTE BETA-ADRENOCEPTOR SENSITIVITY INFLUENCES PLASMA-LIPID LEVELS [J].

ARNER, P ;

WAHRENBERG, H ;

LONNQVIST, F ;

ANGELIN, B .

ARTERIOSCLEROSIS AND THROMBOSIS, 1993, 13 (07) :967-972

[3] βAR signaling required for diet-induced thermogenesis and obesity resistance [J].

Bachman, ES ;

Dhillon, H ;

Zhang, CY ;

Cinti, S ;

Bianco, AC ;

Kobilka, BK ;

Lowell, BB .

SCIENCE, 2002, 297 (5582) :843-845

[4] Correlations among adiposity measures in school-aged children [J].

Boeke, Caroline E. ;

Oken, Emily ;

Kleinman, Ken P. ;

Rifas-Shiman, Sheryl L. ;

Taveras, Elsie M. ;

Gillman, Matthew W. .

BMC PEDIATRICS, 2013, 13

[5] Effects of Childhood Asthma on the Development of Obesity among School-aged Children [J].

Chen, Zhanghua ;

Salam, Muhammad T. ;

Alderete, Tanya L. ;

Habre, Rima ;

Bastain, Theresa M. ;

Berhane, Kiros ;

Gilliland, Frank D. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 195 (09) :1181-1188

[6] Race, Ethnicity, and Socioeconomic Status in Research on Child Health [J].

Cheng, Tina L. ;

Goodman, Elizabeth .

PEDIATRICS, 2015, 135 (01) :E225-E237

[7] Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts [J].

Contreras, Zuelma A. ;

Chen, Zhanghua ;

Roumeliotaki, Theano ;

Annesi-Maesano, Isabella ;

Baiz, Nour ;

von Berg, Andrea ;

Bergstrom, Anna ;

Crozier, Sarah ;

Duijts, Liesbeth ;

Ekstrom, Sandra ;

Eller, Esben ;

Fantini, Maria P. ;

Kjaer, Henrik Fomsgaard ;

Forastiere, Francesco ;

Gerhard, Beatrix ;

Gori, Davide ;

Harskamp-van Ginkel, Margreet W. ;

Heinrich, Joachim ;

Iniguez, Carmen ;

Inskip, Hazel ;

Keil, Thomas ;

Kogevinas, Manolis ;

Lau, Susanne ;

Lehmann, Irina ;

Maier, Dieter ;

van Meel, Evelien R. ;

Mommers, Monique ;

Murcia, Mario ;

Porta, Daniela ;

Smit, Henriette A. ;

Standl, Marie ;

Stratakis, Nikos ;

Sunyer, Jordi ;

Thijs, Carel ;

Torrent, Maties ;

Vrijkotte, Tanja G. M. ;

Wijga, Alet H. ;

Berhane, Kiros ;

Gilliland, Frank ;

Chatzi, Leda .

EUROPEAN RESPIRATORY JOURNAL, 2018, 52 (03)

[8] Changes in Socioeconomic, Racial/Ethnic, and Sex Disparities in Childhood Obesity at School Entry in the United States [J].

Datar, Ashlesha ;

Chung, Paul J. .

JAMA PEDIATRICS, 2015, 169 (07) :696-697

[9] Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies [J].

Egan, Kathryn B. ;

Ettinger, Adrienne S. ;

Bracken, Michael B. .

BMC PEDIATRICS, 2013, 13

[10] Impaired in vivo stimulation of lipolysis in adipose tissue by selective β2-adrenergic agonist in obese adolescent girls [J].

Enoksson, S ;

Talbot, M ;

Rife, F ;

Tamborlane, WV ;

Sherwin, RS ;

Capiro, S .

DIABETES, 2000, 49 (12) :2149-2153

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