Recent applications of Kirkwood-Buff theory to biological systems

被引:194
|
作者
Pierce, Veronica [1 ]
Kang, Myungshim [1 ]
Aburi, Mahalaxmi [1 ]
Weerasinghe, Samantha [1 ,2 ]
Smith, Paul E. [1 ]
机构
[1] Kansas State Univ, Dept Chem, Manhattan, KS 66506 USA
[2] Univ Colombo, Dept Chem, Colombo 00300, Sri Lanka
关键词
preferential binding; preferential interactions; Kirkwood-Buff theory; protein denaturation; cosolvents; osmolytes; computer simulation;
D O I
10.1007/s12013-007-9005-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The effect of cosolvents on biomolecular equilibria has traditionally been rationalized using simple binding models. More recently, a renewed interest in the use of Kirkwood-Buff (KB) theory to analyze solution mixtures has provided new information on the effects of osmolytes and denaturants and their interactions with biomolecules. Here we review the status of KB theory as applied to biological systems. In particular, the existing models of denaturation are analyzed in terms of KB theory, and the use of KB theory to interpret computer simulation data for these systems is discussed.
引用
收藏
页码:1 / 22
页数:22
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