Promoting Cell Migration in Tissue Engineering Scaffolds with Graded Channels

被引：46

作者：

Yang, Degang ^{[2
,3
,4
,5
]}

Zhao, Zhitong ^{[1
]}

Bai, Fan ^{[4
]}

Wang, Shutao ^{[5
,6
]}

Tomsia, Antoni P. ^{[7
]}

Bai, Hao ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Chem & Biol Engn, State Key Lab Chem Engn, Hangzhou 310027, Zhejiang, Peoples R China

[2] China Rehabil Res Ctr, Dept Spinal & Neural Funct Reconstruct, Beijing 100068, Peoples R China

[3] Capital Med Univ, Sch Rehabil Med, Beijing 100068, Peoples R China

[4] China Rehabil Sci Inst, China Rehabil Res Ctr, Beijing Key Lab Neural Injury & Rehabil, Beijing 100068, Peoples R China

[5] Chinese Acad Sci, Tech Inst Phys & Chem, CAS Ctr Excellence Nanosci, CAS Key Lab Bioinspired Mat & Interfacial Sci, Beijing 100190, Peoples R China

[6] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[7] Lawrence Berkeley Natl Lab, Mat Sci Div, Berkeley, CA 94720 USA

来源：

ADVANCED HEALTHCARE MATERIALS | 2017年 / 6卷 / 18期

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

capillarity; cell migration; hydroxyapatite scaffolds; ice-templating; stem cells; POROUS HYDROXYAPATITE SCAFFOLDS; BONE; GRADIENTS;

D O I：

10.1002/adhm.201700472

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Ideal bone scaffolds having good biocompatibility, good biodegradability, and beneficial mechanical properties are the basis for bone tissue engineering. Specifically, cell migration within 3D scaffolds is crucial for bone regeneration of critical size defects. In this research, hydroxyapatite scaffolds with three different types of architectures (tortuous, parallel, and graded channels) are fabricated using the freeze-casting (ice-templating) method. While most studies promote cell migration by chemical factors, it can be greatly enhanced by introducing only graded channels as compared with tortuous or parallel channels. The results provide insights and guidance in designing novel scaffolds to enhance cell migration behavior for bone tissue regeneration.

引用

页数：7

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