Tuberculum sellae meningioma symptomatic during pregnancy: pathophysiological considerations

被引：24

作者：

Ebner, F. H.

Bornemann, A. ^{[2
]}

Wilhelm, H. ^{[3
]}

Ernemann, U. ^{[4
]}

Honegger, J. ^{[1
]}

机构：

[1] Univ Tubingen Hosp, Dept Neurosurg, D-72076 Tubingen, Germany

[2] Univ Tubingen Hosp, Dept Neuropathol, Tubingen, Germany

[3] Univ Tubingen Hosp, Dept Neuroophthalmol, Tubingen, Germany

[4] Univ Tubingen Hosp, Dept Neuroradiol, Tubingen, Germany

来源：

ACTA NEUROCHIRURGICA | 2008年 / 150卷 / 02期

关键词：

pregnancy; meningioma; parasellar lesion; visual impairment;

D O I：

10.1007/s00701-007-1417-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A 31 year old woman in her second pregnancy presented in the 31st (+4) week of gestation with progressive visual impairment of the right eye. Magnetic resonance imaging (MRI) demonstrated a tuberculum sellae meningioma that was displaced upward by a markedly enlarged pituitary gland. Neuro-ophthalmological follow-up examinations showed a progressive decrease of visual acuity and right temporal field loss. Therefore, a caesarean section was performed in the 34th (+8) week. The meningioma was removed three days after childbirth via a right-sided pterional approach. Post-operatively, visual function was completely restored. Immunohistochemical examination showed positive staining for progesterone receptors (PR) in approximately 50% of tumour cells. Enlargement of the pituitary gland during late pregnancy in conjunction with a preexisting tuberculum sellae meningioma is the most likely pathophysiological factor responsible for visual loss. Enlargement of the PR-positive meningioma in the hormonal milieu of pregnancy might have contributed additionally to visual loss.

引用

页码：189 / 193

页数：5

共 33 条

[1] Rapid enlargement and recurrence of a preexisting intrasellar craniopharyngioma during the course of two pregnancies - Case report [J].