Thiadiazole: A new family of intercalative photonuclease with electron transfer and radical mechanisms

被引：18

作者：

Li, YG

Xu, YF

Qian, XH ^{[1
]}

Qu, BY

机构：

[1] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China

[2] E China Univ Sci & Technol, Shanghai 200237, Peoples R China

[3] Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 20期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/S0960-894X(03)00737-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new family of photonuclease, thiadiazole-naphthalimide were synthesized and evaluated. Thiadiazole group was incorporated for the first time. These compounds intercalated into DNA efficiently and damaged DNA as low as 10 muM photochemically. Mechanism experiment showed that electron transfer and radicals were involved. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3513 / 3515

页数：3

共 26 条

[21] Design of DNA-cleaving agents [J].