Thiadiazole: A new family of intercalative photonuclease with electron transfer and radical mechanisms

被引：18

作者：

Li, YG

Xu, YF

Qian, XH ^{[1
]}

Qu, BY

机构：

[1] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China

[2] E China Univ Sci & Technol, Shanghai 200237, Peoples R China

[3] Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 20期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/S0960-894X(03)00737-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new family of photonuclease, thiadiazole-naphthalimide were synthesized and evaluated. Thiadiazole group was incorporated for the first time. These compounds intercalated into DNA efficiently and damaged DNA as low as 10 muM photochemically. Mechanism experiment showed that electron transfer and radicals were involved. (C) 2003 Elsevier Ltd. All rights reserved.

引用

收藏

页码：3513 / 3515

页数：3

相关论文

共 26 条

[11] Benzothiadiazole induces disease resistance in Arabidopsis by activation of the systemic acquired resistance signal transduction pathway [J].

Lawton, KA ;

Friedrich, L ;

Hunt, M ;

Weymann, K ;

Delaney, T ;

Kessmann, H ;

Staub, T ;

Ryals, J .

PLANT JOURNAL, 1996, 10 (01) :71-82

[12] EVALUATION OF AMONAFIDE IN CERVICAL-CANCER, PHASE-II - A SWOG STUDY [J].

MALVIYA, VK ;

LIU, PY ;

ALBERTS, DS ;

SURWIT, EA ;

CRAIG, JB ;

HANNIGAN, EV .

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 1992, 15 (01) :41-44

[13] Pyrazolo-triazoles as light activable DNA cleaving agents [J].

Manfredini, S ;

Vicentini, CB ;

Manfrini, M ;

Bianchi, N ;

Rutigliano, C ;

Mischiati, C ;

Gambari, R .

BIOORGANIC & MEDICINAL CHEMISTRY, 2000, 8 (09) :2343-2346

[14] ELECTRON-SPIN RESONANCE OF IMINOCYCLOHEXADIENYLIDENES - PHOTOINDUCED TRIPLET GEOMETRICAL ISOMERIZATION [J].

MURAI, H ;

TORRES, M ;

STRAUSZ, OP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (04) :1421-1422

[15]

MURIAL H, 1979, J AM CHEM SOC, V101, P3976

[16]

Qian X. H., 2000, J CHEM SOC P2, P715, DOI DOI 10.1039/A908787G

[17] Synthesis and properties of benzothioxanthene dicarboximide hydroperoxide: an efficient 'time-resolved' DNA photocleaver with long-wavelength [J].

Qian, XH ;

Mao, P ;

Yao, W ;

Guo, XF .

TETRAHEDRON LETTERS, 2002, 43 (16) :2995-2998

[18] N-aroyloxynaphthalimides as novel highly efficient DNA photocleavers:: substituent effects [J].

Qian, XH ;

Yao, W ;

Chen, G ;

Huang, XY ;

Mao, P .

TETRAHEDRON LETTERS, 2001, 42 (35) :6175-6178

[19] Nucleic acid oxidation mediated by naphthalene and benzophenone imide and diimide derivatives: Consequences for DNA redox chemistry [J].

Rogers, JE ;

Kelly, LA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (16) :3854-3861

[20] PHASE-I STUDY OF MITONAFIDE IN 120 HOUR CONTINUOUS INFUSION IN NON-SMALL-CELL LUNG-CANCER [J].

ROSELL, R ;

CARLES, J ;

ABAD, A ;

RIBELLES, N ;

BARNADAS, A ;

BENAVIDES, A ;

MARTIN, M .

INVESTIGATIONAL NEW DRUGS, 1992, 10 (03) :171-175