Oral and gut dysbiosis leads to functional alterations in Parkinson's disease

被引：47

作者：

Jo, Sungyang ^{[1
]}

Kang, Woorim ^{[2
,3
,4
]}

Hwang, Yun Su ^{[1
]}

Lee, Seung Hyun ^{[1
]}

Park, Kye Won ^{[5
]}

Kim, Mi Sun ^{[1
]}

Lee, Hyunna ^{[6
]}

Yoon, Hyung Jeong ^{[7
]}

Park, Yoo Kyoung ^{[7
]}

Chalita, Mauricio ^{[4
]}

Lee, Je Hee ^{[4
]}

Sung, Hojun ^{[2
,3
]}

Lee, Jae-Yun ^{[2
,3
]}

Bae, Jin-Woo ^{[2
,3
]}

Chung, Sun Ju ^{[1
]}

机构：

[1] Univ Ulsan, Dept Neurol, Asan Med Ctr, Coll Med, Seoul 05505, South Korea

[2] Kyung Hee Univ, Dept Biol, Seoul 02447, South Korea

[3] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul 02447, South Korea

[4] CJ Biosci Inc, Seoul 04527, South Korea

[5] Eulji Univ, Dept Neurol, Uijeongbu Eulji Med Ctr, Sch Med, Uijeongbu Si 11759, Gyeonggi Do, South Korea

[6] Asan Med Ctr, Bigdata Res Ctr, Asan Inst Life Sci, Seoul 05505, South Korea

[7] Kyung Hee Univ, Dept Med Nutr, Grad Sch East West Med Sci, Yongin 17104, Gyeonggi Do, South Korea

来源：

NPJ PARKINSONS DISEASE | 2022年 / 8卷 / 01期

关键词：

ALPHA-SYNUCLEIN; MICROBIOTA; QUESTIONNAIRE; ASSOCIATION; VALIDATION; REDUNDANCY; SHOTGUN; MODEL;

D O I：

10.1038/s41531-022-00351-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Although several studies have identified a distinct gut microbial composition in Parkinson's disease (PD), few studies have investigated the oral microbiome or functional alteration of the microbiome in PD. We aimed to investigate the connection between the oral and gut microbiome and the functional changes in the PD-specific gut microbiome using shotgun metagenomic sequencing. The taxonomic composition of the oral and gut microbiome was significantly different between PD patients and healthy controls (P = 0.003 and 0.001, respectively). Oral Lactobacillus was more abundant in PD patients and was associated with opportunistic pathogens in the gut (FDR-adjusted P < 0.038). Functional analysis revealed that microbial gene markers for glutamate and arginine biosynthesis were downregulated, while antimicrobial resistance gene markers were upregulated in PD patients than healthy controls (all P < 0.001). We identified a connection between the oral and gut microbiota in PD, which might lead to functional alteration of the microbiome in PD.

引用

页数：12