Syntheses of the opioid substructures 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine and 2,3,4,5-tetrahydro-1,5-methano-1H-2-benzazepine

被引：8

作者：

Coe, Jotham W. ^{[1
]}

Brooks, Paige R. ^{[1
]}

Vetelino, Michael G. ^{[1
]}

Bashore, Crystal G. ^{[1
]}

Bianco, Krista ^{[1
]}

Flick, Andrew C. ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Neurosci Chem, Groton, CT 06340 USA

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 09期

关键词：

NATURAL-PRODUCTS; ANTINOCICEPTIVE ACTIVITY; AZABICYCLO CHEMISTRY; ANALGESICS; DISCOVERY;

D O I：

10.1016/j.tetlet.2010.12.072

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Concise syntheses of 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine (12) and 2,3,4,5-tetrahydro-1,5-methano-1H-2-benzazepine (18) are described and involve an intramolecular Friedel Crafts alkylation and an intramolecular Heck cyclization as their respective key ring-forming steps. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：953 / 954

页数：2

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