Meta-analysis of progesterone supplementation during timed artificial insemination programs in dairy cows

被引:71
作者
Bisinotto, R. S. [1 ]
Lean, I. J. [2 ]
Thatcher, W. W. [1 ]
Santos, J. E. P. [1 ]
机构
[1] Univ Florida, Dept Anim Sci, DH Barron Reprod & Perinatal Biol Res Program, Gainesville, FL 32611 USA
[2] SBScibus, Camden, NSW 2570, Australia
关键词
controlled internal drug release (CIDR); corpus luteum; progesterone; reproduction; OVULATORY FOLLICLE; PREGNANCY RATES; ESTROUS CYCLES; SYNCHRONIZATION PROTOCOLS; OVARIAN-FUNCTION; EMBRYO QUALITY; CORPUS-LUTEUM; FERTILITY; RESYNCHRONIZATION; PRESYNCHRONIZATION;
D O I
10.3168/jds.2014-8954
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
A systematic review of the literature was performed with the objective to evaluate the effects of progesterone supplementation using a single intravaginal insert during timed artificial insemination (AI) programs on fertility in lactating dairy cows. A total of 25 randomized controlled studies including 8,285 supplemented cows and 8,398 untreated controls were included in the meta-analysis. Information regarding the presence of corpus luteum (CL) at the initiation of the synchronization protocol was available for 6,883 supplemented cows and 6,879 untreated controls in 21 experiments. Studies were classified based on service number (first AI vs. resynchronized AI), use of presynchronization (yes vs. no), and insemination of cows in estrus during the synchronization protocol (inseminated in estrus and timed AI vs. timed AI only). Reproductive outcomes of interest were pregnancy per AI (P/AI) measured on d 32 (27 to 42) and 60 (41 to 71) after AI, and pregnancy loss between d 32 and 60 of gestation. Random effects meta-analyses were conducted and treatment effect was summarized into a pooled risk ratio with the Knapp-Hartung modification (RRK+H). The effect of moderator variables was assessed using meta-regression analyses. Progesterone supplementation increased the risk of pregnancy on d 32 [RRK+H = 1.08; 95% confidence interval (CI) = 1.02-1.14] and 60 after AI (RRK+H = 1.10; 95% CI = 1.03-1.17). The benefit of progesterone supplementation was observed mainly in cows lacking a CL at the initiation of the timed AI program (d 60: RRK+H = 1.18; 95% CI = 1.07-1.30) rather than those with CL (d 60: RRK+H = 1.06; 95% CI = 0.99-1.12). Progesterone supplementation benefited P/AI in studies in which all cows were inseminated at timed AI (d 60: RRK+H = 1.20; 95% CI = 1.10-1.29), but not in studies in which cows could be inseminated in estrus during the timed AI program (d 60: RRK+H = 1.04; 95% CI = 0.92-1.16). Progesterone supplementation tended to reduce the risk of pregnancy loss ( RRK+H = 0.84; 95% CI = 0.67-1.00). Service number and presynchronization did not influence the effect of progesterone supplementation on fertility. In summary, progesterone supplementation using a single intravaginal insert during the timed AI program increased P/AI mostly in cows without CL and reduced the risk of pregnancy loss in lactating dairy cows. Insemination of cows in estrus during the synchronization protocol eliminated the benefit of supplemental progesterone on P/AI.
引用
收藏
页码:2472 / 2487
页数:16
相关论文
共 51 条
[1]   Synchronization and resynchronization of inseminations in lactating dairy cows with the CIDR insert and the Ovsynch protocol [J].
Bartolome, J. A. ;
van Leeuwen, J. J. J. ;
Thieme, M. ;
Sa'filho, O. G. ;
Melendez, P. ;
Archbald, L. F. ;
Thatcher, W. W. .
THERIOGENOLOGY, 2009, 72 (06) :869-878
[2]   Supplemental progesterone and timing of resynchronization on pregnancy outcomes in lactating dairy cows [J].
Bilby, T. R. ;
Bruno, R. G. S. ;
Lager, K. J. ;
Chebel, R. C. ;
Moraes, J. G. N. ;
Fricke, P. M. ;
Lopes, G., Jr. ;
Giordano, J. O. ;
Santos, J. E. P. ;
Lima, F. S. ;
Stevenson, J. S. ;
Pulley, S. L. .
JOURNAL OF DAIRY SCIENCE, 2013, 96 (11) :7032-7042
[3]   The use of endocrine treatments to improve pregnancy rates in cattle [J].
Bisinotto, R. S. ;
Santos, J. E. P. .
REPRODUCTION FERTILITY AND DEVELOPMENT, 2012, 24 (01) :258-266
[4]   Effect of progesterone supplementation on fertility responses of lactating dairy cows with corpus luteum at the initiation of the Ovsynch protocol [J].
Bisinotto, R. S. ;
Pansani, M. B. ;
Castro, L. O. ;
Narciso, C. D. ;
Sinedino, L. D. P. ;
Martinez, N. ;
Carneiro, P. E. ;
Thatcher, W. W. ;
Santos, J. E. P. .
THERIOGENOLOGY, 2015, 83 (02) :257-265
[5]   Synchronisation of ovulation for management of reproduction in dairy cows [J].
Bisinotto, R. S. ;
Ribeiro, E. S. ;
Santos, J. E. P. .
ANIMAL, 2014, 8 :151-159
[6]   Targeted progesterone supplementation improves fertility in lactating dairy cows without a corpus luteum at the initiation of the timed artificial insemination protocol [J].
Bisinotto, R. S. ;
Ribeiro, E. S. ;
Lima, F. S. ;
Martinez, N. ;
Greco, L. F. ;
Barbosa, L. F. S. P. ;
Bueno, P. P. ;
Scagion, L. F. S. ;
Thatcher, W. W. ;
Santos, J. E. P. .
JOURNAL OF DAIRY SCIENCE, 2013, 96 (04) :2214-2225
[7]   Effect of interval between induction of ovulation and artificial insemination (AI) and supplemental progesterone for resynchronization on fertility of dairy cows subjected to a 5-d timed AI program [J].
Bisinotto, R. S. ;
Ribeiro, E. S. ;
Martins, L. T. ;
Marsola, R. S. ;
Greco, L. F. ;
Favoreto, M. G. ;
Risco, C. A. ;
Thatcher, W. W. ;
Santos, J. E. P. .
JOURNAL OF DAIRY SCIENCE, 2010, 93 (12) :5798-5808
[8]   Follicular wave of the ovulatory follicle and not cyclic status influences fertility of dairy cows [J].
Bisinotto, R. S. ;
Chebel, R. C. ;
Santos, J. E. P. .
JOURNAL OF DAIRY SCIENCE, 2010, 93 (08) :3578-3587
[9]   Association between ovarian follicle development and pregnancy rates in dairy cows undergoing spontaneous oestrous cycles [J].
Bleach, ECL ;
Glencross, RG ;
Knight, PG .
REPRODUCTION, 2004, 127 (05) :621-629
[10]   Concentration of progesterone during the development of the ovulatory follicle: II. Ovarian and uterine responses [J].
Cerri, R. L. A. ;
Chebel, R. C. ;
Rivera, F. ;
Narciso, C. D. ;
Oliveira, R. A. ;
Amstalden, M. ;
Baez-Sandoval, G. M. ;
Oliveira, L. J. ;
Thatcher, W. W. ;
Santos, J. E. P. .
JOURNAL OF DAIRY SCIENCE, 2011, 94 (07) :3352-3365