Alzheimer's disease and anaesthesia: Potential relationships and clinical implications

被引：2

作者：

Andre, D. ^{[1
]}

Dartigues, J. -F. ^{[2
]}

Sztark, F. ^{[1
]}

机构：

[1] Univ Bordeaux 2, CHU Bordeaux, Grp Hosp Pellegrin, Serv Anesthesie Reanimat 1, F-33076 Bordeaux, France

[2] Univ Bordeaux 2, INSERM, U897, F-33076 Bordeaux, France

来源：

ANNALES FRANCAISES D ANESTHESIE ET DE REANIMATION | 2011年 / 30卷 / 01期

关键词：

Alzheimer's disease; Postoperative cognitive dysfunction; Anaesthetics neurotoxicity; POSTOPERATIVE COGNITIVE DYSFUNCTION; NITROUS OXIDE ANESTHESIA; ISOFLURANE INDUCES APOPTOSIS; INDUCED NEURONAL APOPTOSIS; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN-E GENOTYPE; BETA-PEPTIDE; GLUCOSE DEPRIVATION; INTRACELLULAR CA2+; GENERAL-ANESTHESIA;

D O I：

10.1016/j.annfar.2010.10.013

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Alzheimer's disease is the most common form of dementia. As the aging population increases, Alzheimer's disease is becoming a major concern of Public Health. Many molecular lesions have been detected in Alzheimer's disease, but physiopathology is still poorly understood. If the neurotoxicity of anaesthetics in human remains debatable, perioperative period is certainly a high-risk factor for cognitive impairment, especially in elderly population. Large clinical studies are required to develop new strategies for perioperative management in such patients, including the adjustment of anaesthesia techniques. Before that, information of patient and its relatives and a particular attention for elderly during anaesthesia and perioperative period should be considered. (C) 2010 Elsevier Masson SAS. Tous droits reserves.

引用

页码：37 / 46

页数：10

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