Exploring the link between innate immune activation and thymic function by measuring sCD14 and TRECs in HIV patients living in Belgium

被引：13

作者：

De Voeght, Adrien ^{[1
,2
]}

Martens, Henri ^{[3
]}

Renard, Chantal ^{[3
]}

Vaira, Dolores ^{[4
]}

Debruche, Mathieu ^{[3
]}

Simonet, Julie ^{[1
]}

Geenen, Vincent ^{[3
]}

Moutschen, Michel ^{[1
,2
,4
]}

Darcis, Gilles ^{[1
]}

机构：

[1] Univ Liege, Univ Hosp Ctr Liege, Infect Dis Dept, Liege, Belgium

[2] Univ Liege, GIGA Res Inst, Lab Immunol & Infect Dis, GIGA Inflammat Infect & Immun, Liege, Belgium

[3] Univ Liege, Dept Biomed & Preclin Sci, GIGA I Ctr Immunoendocrinol 3, GIGA Res Inst, Liege, Belgium

[4] Univ Liege, AIDS Reference Ctr, Univ Hosp Ctr Liege, Liege, Belgium

来源：

PLOS ONE | 2017年 / 12卷 / 10期

关键词：

SOLUBLE CD14; MICROBIAL TRANSLOCATION; LIPOPOLYSACCHARIDE RECEPTOR; GASTROINTESTINAL-TRACT; DISEASE PROGRESSION; CELL DEPLETION; INFECTION; SUPPRESSION; EXPRESSION; ASSOCIATION;

D O I：

10.1371/journal.pone.0185761

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Microbial translocation is now viewed as a central event in the pathogenesis of chronic inflammation during HIV infection. Thymic function failure is another crucial factor involved in HIV disease progression. The goal of this study was to explore the hypothesis of potential links between microbial translocation and thymic function in HIV-1 patients living in Belgium. The extent of microbial translocation was assessed through the measurement of soluble CD14 (sCD14). T-cell receptor excision circles (sjTRECs and d beta TRECs) were used as a measure of thymic function. Data were collected from 75 HIV-infected patients. Simple and complex linear regressions were done to analyze the link between these two processes. We found a statistically relevant negative correlation between thymopoiesis (sjTREC) and sCD14 level (p = 0.004). These results suggest a link between thymic function failure, microbial translocation and innate immune activation.

引用

页数：11

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