Evaluation of Nigerian traditional medicines: II. effects of some Nigerian folk remedies on peptic ulcer

被引：68
作者：
Akah, PA [1 ]
Orisakwe, OE
Gamaniel, KS
Shittu, A
机构：
[1] Univ Nigeria, Dept Pharmacol & Toxicol, Nsukka, Nigeria
[2] Nnamdi Azikiwe Univ, Dept Pharmacol & Toxicol, Awka, Nigeria
[3] Natl Inst Pharmaceut Res & Dev, Dept Pharmacol & Toxicol, Abuja, Nigeria
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 1998年 / 62卷 / 02期
关键词：
traditional medicines in Nigeria; gastric secretion; anti-ulcer;
D O I：
10.1016/S0378-8741(98)00060-9
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Antiulcer activity of four medicinal plants, Diodia sarmentosa (whole plant), Cassia nigricans (leaves), Ficus exasperata (leaves) and Synclisia scabrida (leaves), which are commonly used by the Nigerian traditional healers for the treatment of peptic ulcer were investigated. Acute toxicity tests were also carried out. The results revealed that the four extracts possess significant anti-ulcerogenic properties in a dose-dependent way. They protected rats from aspirin-induced ulcerogenesis, delayed intestinal transit, increased the pH, and decreased both the Volume and acidity of gastric secretion. These results correlate with local use of the plants. (C) 1998 Elsevier Science ireland Ltd. All rights reserved.
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收藏
页码：123 / 127
页数：5
相关论文
共 28 条
[1]  
AKAH P A, 1989, Fitoterapia, V60, P45
[2]  
Akah P. A., 1993, Fitoterapia, V64, P42
[3]   ABORTIFACIENT ACTIVITY OF SOME NIGERIAN MEDICINAL-PLANTS [J].
AKAH, PA .
PHYTOTHERAPY RESEARCH, 1994, 8 (02) :106-108
[4]   EVALUATION OF NIGERIAN TRADITIONAL MEDICINES .1. PLANTS USED FOR RHEUMATIC (INFLAMMATORY) DISORDERS [J].
AKAH, PA ;
NWAMBIE, AI .
JOURNAL OF ETHNOPHARMACOLOGY, 1994, 42 (03) :179-182
[5]  
AKAH PA, 1995, FITOTERAPIA, V65, P351
[6]  
AOYGI J, 1966, ANN INTERN MED, V117, P667
[7]   A METAANALYSIS COMPARING THE EFFICACY OF OMEPRAZOLE WITH H-2-RECEPTOR ANTAGONISTS FOR ACUTE TREATMENT OF DUODENAL-ULCER IN ASIAN PATIENTS [J].
BAMBERG, P ;
CASWELL, CM ;
FRAME, MH ;
LAM, SK ;
WONG, ECK .
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 1992, 7 (06) :577-585
[8]  
BARROWMAN JA, 1992, DRUGS PEPTIC ULCER, P123
[9]   EFFECT OF SUBSTANCE-P AND ITS NATURAL ANALOGS ON GASTRIC-EMPTYING OF THE CONSCIOUS RAT [J].
BERTACCINI, G ;
DECASTIGLIONE, R ;
SCARPIGNATO, C .
BRITISH JOURNAL OF PHARMACOLOGY, 1981, 72 (02) :221-223
[10]  
BERTACCINI G, 1982, BRIT J PHARMACOL, V77, P434
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