Lysosomal exocytosis induced by hyperthermia: A new model of cancer death .3. Effect on liver metastasis

被引：7
作者：
Barni, S
Bertone, V
Silvotti, MG
Freitas, I
Mathe, G
Pontiggia, P
机构：
[1] CNR,CTR HISTOCHEM,I-27100 PAVIA,ITALY
[2] CLIN CITTA PAVIA,DEPT ONCOL,I-27100 PAVIA,ITALY
[3] HOP SUISSE PARIS,INST CANCEROL & IMMUNOL,F-92130 ISSY MOULINEAUX,FRANCE
来源：
BIOMEDICINE & PHARMACOTHERAPY | 1996年 / 50卷 / 02期
关键词：
hyperthermia; liver metastasis; lysosomes; macrophages;
D O I：
10.1016/0753-3322(96)84717-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The purpose of the present study was to evaluate by morphological approaches (light and electron microscopy), the effect of hyperthermic treatment in one case of human liver metastasis. The results demonstrate that hyperthermia causes a significant reduction of the metastatic cells circulating into sinusoids and the ''normalization'' of the hepatocytes substructure. The data are consistent with a direct and/or indirect action of the temperature on the presence of infiltrating tumor cells. Particular importance is attributed to a general activation of lysosomes present in neoplastic cells, Kupffer calls and hepatocytes.
引用
收藏
页码：79 / 84
页数：6
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