Semiconducting Polymer Nanoparticles for Centimeters-Deep Photoacoustic Imaging in the Second Near-Infrared Window

被引：143

作者：

Wu, Jiayingzi ^{[1
]}

You, Liyan ^{[1
]}

Lan, Lu ^{[2
]}

Lee, Hyeon Jeong ^{[2
,3
]}

Chaudhry, Saadia T. ^{[1
]}

Li, Rui ^{[2
]}

Cheng, Ji-Xin ^{[1
,2
]}

Mei, Jianguo ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

[2] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA

[3] Purdue Univ, Interdisciplinary Life Sci Program, W Lafayette, IN 47907 USA

来源：

ADVANCED MATERIALS | 2017年 / 29卷 / 41期

关键词：

contrast agents; deep tissue; near-infrared; photoacoustic imaging; semiconducting polymer nanoparticles; CONTRAST AGENT; TOMOGRAPHY; ANGIOGENESIS; REFLECTANCE; MODEL; NM;

D O I：

10.1002/adma.201703403

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Thienoisoindigo-based semiconducting polymer with a strong near-infrared absorbance is synthesized and its water-dispersed nanoparticles (TSPNs) are investigated as a contrast agent for photoacoustic (PA) imaging in the second near-infrared (NIR-II) window (1000-1350 nm). The TSPNs generate a strong PA signal in the NIR-II optical window, where background signals from endogenous contrast agents, including blood and lipid, are at the local minima. By embedding a TSPN-containing tube in chicken-breast tissue, an imaging depth of more than 5 cm at 1064 nm excitation is achieved with a contrast-agent concentration as low as 40 mu g mL(-1). The TSPNs under the skin or in the tumor are clearly visualized at 1100 and 1300 nm, with negligible interference from the tissue background. TSPN as a PA contrast in the NIR-II window opens new opportunities for biomedical imaging of deep tissues with improved contrast.

引用

页数：6

共 46 条

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