Gene expression profiling of normal thyroid tissue from patients with thyroid carcinoma

被引：11

作者：

Ria, Roberto ^{[1
]}

Simeon, Vittorio ^{[2
]}

Melaccio, Assunta ^{[1
]}

Di Meo, Giovanna ^{[3
]}

Trino, Stefania ^{[2
]}

Mazzoccoli, Carmela ^{[2
]}

Saltarella, Ilaria ^{[1
]}

Lamanuzzi, Aurelia ^{[1
]}

Morano, Annalisa ^{[2
]}

Gurrado, Angela ^{[3
]}

Pasculli, Alessandro ^{[3
]}

Lastilla, Gaetano ^{[4
]}

Musto, Pellegrino ^{[2
]}

Reale, Antonia ^{[1
]}

Dammacco, Franco ^{[1
]}

Vacca, Angelo ^{[1
]}

Testini, Mario ^{[3
]}

机构：

[1] Sect Internal Med G Baccelli, Dept Biomed Sci & Human Oncol, Bari, BA, Italy

[2] IRCSS CROB, Lab Preclin & Traslat Res, Rionero In Vulture, PZ, Italy

[3] Dept Biomed Sci & Human Oncol, Unit Endocrine Digest & Emergency Surg, Bari, BA, Italy

[4] Univ Bari Aldo Moro, Dept Pathol, Sch Med, Bari, BA, Italy

来源：

ONCOTARGET | 2016年 / 7卷 / 20期

基金：

欧盟第七框架计划;

关键词：

gene expression profile; hypoxia; microenvironment; oncogenes; thyroid cancer; MARROW ENDOTHELIAL-CELLS; INDUCIBLE FACTOR 1-ALPHA; MULTIPLE-MYELOMA; TUMOR MICROENVIRONMENT; CANCER; PAPILLARY; OVEREXPRESSION; ANGIOGENESIS; PROGNOSIS; MARKERS;

D O I：

10.18632/oncotarget.8820

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gene expression profiling (GEP) of normal thyroid tissue from 43 patients with thyroid carcinoma, 6 with thyroid adenoma, 42 with multinodular goiter, and 6 with Graves-Basedow disease was carried out with the aim of achieving a better understanding of the genetic mechanisms underlying the role of normal cells surrounding the tumor in the thyroid cancer progression. Unsupervised and supervised analyses were performed to compare samples from neoplastic and non-neoplastic diseases. GEP and subsequent RT-PCR analysis identified 28 differentially expressed genes. Functional assessment revealed that they are involved in tumorigenesis and cancer progression. The distinct GEP is likely to reflect the onset and/or progression of thyroid cancer, its molecular classification, and the identification of new potential prognostic factors, thus allowing to pinpoint selective gene targets with the aim of realizing more precise preoperative diagnostic procedures and novel therapeutic approaches.

引用

页码：29677 / 29688

页数：12

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