On-chip temperature gradient liquid chromatography

被引：5

作者：

Shih, CY ^{[1
]}

Chen, Y ^{[1
]}

Xie, J ^{[1
]}

He, Q ^{[1
]}

Tai, YC ^{[1
]}

机构：

[1] CALTECH, Pasadena, CA 91125 USA

来源：

MEMS 2005 Miami: Technical Digest | 2005年

关键词：

D O I：

10.1109/MEMSYS.2005.1454046

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

We report here the first MEMS temperature-programmable high pressure parylene column with integrated thermal isolation and electrochemical sensor for on-chip temperature gradient liquid chromatography. Two sets of devices for different high performance liquid chromatography (HPLC) criteria were fabricated. The separation and detection of derivatized amino acids sample was successfully demonstrated. Compared with other temperature gradient HPLC systems which use "macro oven" to generate temporal temperature gradient in the column, our device's thermal performance is greatly improved by orders of magnitude without the sacrifice of chromatography quality.

引用

页码：782 / 785

页数：4

共 50 条

[31] On-Chip Step-Mixing in a T-Nanomixer for Liquid Chromatography in Extended-Nanochannels
Smirnova, Adelina
Shimizu, Hisashi
Pihosh, Yuriy
Mawatari, Kazuma
Kitamori, Takehiko
ANALYTICAL CHEMISTRY, 2016, 88 (20) : 10059 - 10064
[32] Pillar-structured microchannell's for on-chip liquid chromatography: Evaluation of the permeability and separation performance
De Pra, Mauro
De Malsche, Wim
Desmet, Gert
Schoenmakers, Peter J.
Kok, Wim Th.
JOURNAL OF SEPARATION SCIENCE, 2007, 30 (10) : 1453 - 1460
[33] SHUNT REGULATOR WITH ON-CHIP TEMPERATURE PROTECTION
RADNAI, R
ELECTRONIC ENGINEERING, 1978, 50 (605): : 11 - 11
[34] Temperature-aware on-chip networks
Shang, L
Peh, LS
Kumar, A
Jha, NK
IEEE MICRO, 2006, 26 (01) : 130 - 139
[35] Temperature Effects on On-Chip Energy Measurements
Cebrian, Juan M.
Natvig, Lasse
2013 INTERNATIONAL GREEN COMPUTING CONFERENCE (IGCC), 2013,
[36] Effect of temperature on gradient reequilibration in reversed-phase liquid chromatography
Coym, Jason W.
Roe, Brian W.
JOURNAL OF CHROMATOGRAPHY A, 2007, 1154 (1-2) : 182 - 188
[37] Thermostatted Micro Gas Chromatography Column with On-chip Thermal Conductivity Detector for Elevated Temperature Separation
Narayanan, Shree
Alfeeli, Bassam
Agah, Masoud
2010 IEEE SENSORS, 2010, : 2504 - 2507
[38] Axial temperature gradient and mobile phase gradient in microcolumn high-performance liquid chromatography
Tian, Hongzhe
Xu, Jing
Guan, Yafeng
TALANTA, 2007, 72 (02) : 813 - 818
[39] On-line on-chip post-column derivatisation reactions for pre-ionisation of analytes and cluster analysis in gradient μ-liquid chromatography/electrospray mass spectrometry
Spikmans, V
Lane, SJ
Leavens, B
Manz, A
Smith, NW
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2002, 16 (14) : 1377 - 1388
[40] On-chip hydrodynamic chromatography separation and detection of nanoparticles and biomolecules
Blom, MT
Chmela, E
Oosterbroek, RE
Tijssen, R
van den Berg, A
ANALYTICAL CHEMISTRY, 2003, 75 (24) : 6761 - 6768

← 1 2 3 4 5 →