Minireview: Inflammation and Obesity Pathogenesis: The Hypothalamus Heats Up

被引：212
作者：
Thaler, Joshua P. [1 ]
Schwartz, Michael W. [1 ]
机构：
[1] Univ Washington, Div Metab Endocrinol & Nutr, Seattle, WA 98109 USA
来源：
ENDOCRINOLOGY | 2010年 / 151卷 / 09期
基金：
美国国家卫生研究院;
关键词：
DIET-INDUCED OBESE; NERVOUS-SYSTEM CONTROL; INSULIN-RESISTANCE; LEPTIN RESISTANCE; BODY-WEIGHT; FATTY-ACIDS; FOOD-INTAKE; SENSITIVITY; STRESS; ACCUMULATION;
D O I：
10.1210/en.2010-0336
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Obesity induced by high-fat (HF) feeding is associated with low-grade inflammation in peripheral tissues that predisposes to insulin resistance. Recent evidence suggests the occurrence of a similar process in the hypothalamus, which favors weight gain through impairment of leptin and insulin signaling. In addition to its implications for obesity pathogenesis, this hypothesis suggests that centrally targeted antiinflammatory therapies may prove effective in prevention and treatment of this disorder. This article highlights molecular and cellular mechanisms by which hypothalamic inflammation predisposes to diet-induced obesity. (Endocrinology 151: 4109-4115, 2010)
引用
收藏
页码：4109 / 4115
页数：7
相关论文
共 58 条
  • [41] Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones.
    Rosenbaum, M
    Murphy, EM
    Heymsfield, SB
    Matthews, DE
    Leibel, RL
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (05) : 2391 - 2394
  • [42] Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1
    Sabio, Guadalupe
    Cavanagh-Kyros, Julie
    Barrett, Tamera
    Jung, Dae Young
    Ko, Hwi Jin
    Ong, Helena
    Morel, Caroline
    Mora, Alfonso
    Reilly, Judith
    Kim, Jason K.
    Davis, Roger J.
    [J]. GENES & DEVELOPMENT, 2010, 24 (03) : 256 - 264
  • [43] Human IL6 enhances leptin action in mice
    Sadagurski, M.
    Norquay, L.
    Farhang, J.
    D'Aquino, K.
    Copps, K.
    White, M. F.
    [J]. DIABETOLOGIA, 2010, 53 (03) : 525 - 535
  • [44] Insulin sensitivity: modulation by nutrients and inflammation
    Schenk, Simon
    Saberi, Maziyar
    Olefsky, Jerrold M.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (09) : 2992 - 3002
  • [45] Central nervous system control of food intake
    Schwartz, MW
    Woods, SC
    Porte, D
    Seeley, RJ
    Baskin, DG
    [J]. NATURE, 2000, 404 (6778) : 661 - 671
  • [46] Inflammation and insulin resistance
    de Luca, Carl
    Olefsky, Jerrold M.
    [J]. FEBS LETTERS, 2008, 582 (01): : 97 - 105
  • [47] Effects of bariatric surgery on mortality in Swedish obese subjects
    Sjostrom, Lars
    Narbro, Kristina
    Sjostrom, David
    Karason, Kristjan
    Larsson, Bo
    Wedel, Hans
    Lystig, Ted
    Sullivan, Marianne
    Bouchard, Claude
    Carlsson, Bjorn
    Bengtsson, Calle
    Dahlgren, Sven
    Gummesson, Anders
    Jacobson, Peter
    Karlsson, Jan
    Lindroos, Anna-Karin
    Lonroth, Hans
    Naslund, Ingmar
    Olbers, Torsten
    Stenlof, Kaj
    Torgerson, Jarl
    Agren, Goran
    Carlsson, Lena M. S.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (08) : 741 - 752
  • [48] Comparison of strategies for sustaining weight loss - The weight loss maintenance randomized controlled trial
    Svetkey, Laura P.
    Stevens, Victor J.
    Brantley, Phillip J.
    Appel, Lawrence J.
    Hollis, Jack F.
    Loria, Catherine M.
    Vollmer, William M.
    Gullion, Christina M.
    Funk, Kristine
    Smith, Patti
    Samuel-Hodge, Carmen
    Myers, Valerie
    Lien, Lillian F.
    Laferriere, Daniel
    Kennedy, Betty
    Jerome, Gerald J.
    Heinith, Fran
    Harsha, David W.
    Evans, Pamela
    Erlinger, Thomas P.
    Dalcin, Arline T.
    Coughlin, Janelle
    Charleston, Jeanne
    Champagne, Catherine M.
    Bauck, Alan
    Ard, Jamy D.
    Aicher, Kathleen
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 299 (10): : 1139 - 1148
  • [49] Hypothalamic inflammation and energy homeostasis: Resolving the paradox
    Thaler, Joshua P.
    Choi, Sun Ju
    Schwartz, Michael W.
    Wisse, Brent E.
    [J]. FRONTIERS IN NEUROENDOCRINOLOGY, 2010, 31 (01) : 79 - 84
  • [50] Atypical Protein Kinase C Activity in the Hypothalamus Is Required for Lipopolysaccharide-Mediated Sickness Responses
    Thaler, Joshua P.
    Choi, Sun Ju
    Sajan, Mini P.
    Ogimoto, Kayoko
    Nguyen, Hong T.
    Matsen, Miles
    Benoit, Stephen C.
    Wisse, Brent E.
    Farese, Robert V.
    Schwartz, Michael W.
    [J]. ENDOCRINOLOGY, 2009, 150 (12) : 5362 - 5372
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