Minireview: Inflammation and Obesity Pathogenesis: The Hypothalamus Heats Up

被引：212
作者：
Thaler, Joshua P. [1 ]
Schwartz, Michael W. [1 ]
机构：
[1] Univ Washington, Div Metab Endocrinol & Nutr, Seattle, WA 98109 USA
来源：
ENDOCRINOLOGY | 2010年 / 151卷 / 09期
基金：
美国国家卫生研究院;
关键词：
DIET-INDUCED OBESE; NERVOUS-SYSTEM CONTROL; INSULIN-RESISTANCE; LEPTIN RESISTANCE; BODY-WEIGHT; FATTY-ACIDS; FOOD-INTAKE; SENSITIVITY; STRESS; ACCUMULATION;
D O I：
10.1210/en.2010-0336
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Obesity induced by high-fat (HF) feeding is associated with low-grade inflammation in peripheral tissues that predisposes to insulin resistance. Recent evidence suggests the occurrence of a similar process in the hypothalamus, which favors weight gain through impairment of leptin and insulin signaling. In addition to its implications for obesity pathogenesis, this hypothesis suggests that centrally targeted antiinflammatory therapies may prove effective in prevention and treatment of this disorder. This article highlights molecular and cellular mechanisms by which hypothalamic inflammation predisposes to diet-induced obesity. (Endocrinology 151: 4109-4115, 2010)
引用
收藏
页码：4109 / 4115
页数：7
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