Dynamic Human Environmental Exposome Revealed by Longitudinal Personal Monitoring

被引：134

作者：

Jiang, Chao ^{[1
]}

Wang, Xin ^{[1
]}

Li, Xiyan ^{[1
]}

Inlora, Jingga ^{[1
]}

Wang, Ting ^{[1
]}

Liu, Qing ^{[1
]}

Snyder, Michael ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94304 USA

来源：

CELL | 2018年 / 175卷 / 01期

基金：

美国国家卫生研究院;

关键词：

EVOLUTION; EXPOSURE;

D O I：

10.1016/j.cell.2018.08.060

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human health is dependent upon environmental exposures, yet the diversity and variation in exposures are poorly understood. We developed a sensitive method to monitor personal airborne biological and chemical exposures and followed the personal exposomes of 15 individuals for up to 890 days and over 66 distinct geographical locations. We found that individuals are potentially exposed to thousands of pan-domain species and chemical compounds, including insecticides and carcinogens. Personal biological and chemical exposomes are highly dynamic and vary spatiotemporally, even for individuals located in the same general geographical region. Integrated analysis of biological and chemical exposomes revealed strong location-dependent relationships. Finally, construction of an exposome interaction network demonstrated the presence of distinct yet interconnected human-and environment-centric clouds, comprised of interacting ecosystems such as human, flora, pets, and arthropods. Overall, we demonstrate that human exposomes are diverse, dynamic, spatiotemporally-driven interaction networks with the potential to impact human health.

引用

页码：277 / +

页数：46

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