Surveillance of antimicrobial resistance in Lebanese hospitals: retrospective nationwide compiled data

被引：99

作者：

Chamoun, Kamal ^{[1
]}

Farah, Maya ^{[1
]}

Araj, Georges ^{[2
]}

Daoud, Ziad ^{[3
,4
]}

Moghnieh, Rima ^{[20
]}

Salameh, Pascale ^{[5
]}

Saade, Danielle ^{[6
]}

Mokhbat, Jacques ^{[7
]}

Abboud, Emme ^{[8
]}

Hamze, Monzer ^{[9
]}

Abboud, Edmond ^{[10
]}

Jisr, Tamima ^{[11
]}

Haddad, Antoine ^{[12
]}

Feghali, Rita ^{[13
]}

Azar, Nadim ^{[14
]}

El-Zaatari, Mohammad ^{[15
]}

Chedid, Marwan ^{[16
]}

Haddad, Christian ^{[17
]}

Nehme, Mireille Zouain Dib ^{[18
]}

Barakat, Angelique ^{[19
]}

Husni, Rola ^{[7
]}

机构：

[1] Lebanese Amer Univ, Med Ctr, Rizk Hosp, Dept Internal Med, Beirut, Lebanon

[2] Amer Univ Beirut, Med Ctr, Dept Microbiol, Beirut, Lebanon

[3] Univ Balamand, Fac Med, Dept Microbiol, Beirut, Lebanon

[4] Ctr Hosp Nord Hosp, Beirut, Lebanon

[5] Lebanese Amer Univ, Dept Pharm Practice, Sch Pharm, Byblos, Lebanon

[6] Minist Publ Hlth, Epidemiol Surveillance Unit, Beirut, Lebanon

[7] Lebanese Amer Univ, Rizk Hosp, Div Infect Dis, Dept Internal Med, Beirut, Lebanon

[8] Mt Lebanon Hosp, Dept Microbiol, Beirut, Lebanon

[9] NINI Hosp, Dept Microbiol0, Tripoli, Lebanon

[10] Middle East Inst Hlth, Dept Microbiol, Mt Lebanon, Lebanon

[11] Makassed Hosp, Dept Microbiol, Beirut, Lebanon

[12] Sacre Coeur Hosp, Department Microbiol, Mt Lebanon, Lebanon

[13] Rafik Hariri Univ Hosp, Dept Microbiol, Beirut, Lebanon

[14] Hotel Dieu de France Hosp, Dept Microbiol, Beirut, Lebanon

[15] Hammoud Hosp, Dept Microbiol, Saida, Lebanon

[16] Mazloum Hosp, Dept Microbiol, Tripoli, Lebanon

[17] Notre Dame des Secours Hosp, Dept Microbiol, Byblos, Lebanon

[18] Abou Jaoude Hosp, Dept Microbiol, Mt Lebanon, Lebanon

[19] Bellevue Hosp, Dept Microbiol, Mt Lebanon, Lebanon

[20] Makassed Hosp, Dept Infect Dis, Beirut, Lebanon

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2016年 / 46卷

关键词：

Gram-negative bacteria; Gram-positive bacteria; Susceptibility; Resistance; Lebanon; BETA-LACTAMASE PRODUCTION; STREPTOCOCCUS-PNEUMONIAE; SUSCEPTIBILITY PATTERNS; PHENOTYPIC DETECTION; PREVALENCE; SOUTHERN; GENE; MRSA;

D O I：

10.1016/j.ijid.2016.03.010

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Antimicrobial resistance is closely linked to antimicrobial use and is a growing concern worldwide. Antimicrobial resistance increases healthcare costs substantially in many countries, including Lebanon. National data from Lebanon have, in the most part, been limited to a few academic hospitals. The Lebanese Society of Infectious Diseases conducted a retrospective study to better describe the antimicrobial susceptibility patterns of bacterial isolates in Lebanon. Data were based on records retrieved from the bacteriology laboratories of 16 different Lebanese hospitals between January 2011 and December 2013. The susceptibility results of a total 20 684 Gram-positive and 55 594 Gram-negative bacteria were analyzed. The prevalence rate of methicillin-resistant Staphylococcus aureus was 27.6% and of vancomycin-resistant Enterococcus spp was 1%. Streptococcus pneumoniae had susceptibilities of 46% to oxacillin, 63% to erythromycin, and 98% to levofloxacin. Streptococcus pyogenes had susceptibilities of 94% to erythromycin and 95% to clindamycin. The mean ampicillin susceptibility of Haemophilus influenzae, Salmonella spp, and Shigella spp isolates was 79%, 81.3%, and 62.2%, respectively. The extended -spectrum beta-lactamase production rate for Escherichia coli was 32.3% and for Klebsiella spp was 29.2%. Acinetobacter spp showed high resistance to most antimicrobials, with low resistance to colistin (17.1%). Pseudomonas spp susceptibilities to piperacillin-tazobactam and imipenem were lower than 80% (79.7% and 72.8%, respectively). This study provides population -specific data that are valuable in guiding antimicrobial use in Lebanon and neighbouring countries and will help in the establishment of a surveillance system for antimicrobial resistance following the implementation of a nationwide standardization of laboratory methods and data entry. (C) 2016 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org.Licensesiby-nd 4.0/)

引用

页码：64 / 70

页数：7

共 28 条

[1]

[Anonymous], 2013, Antibiotic resistance threats in the United States

[2]

[Anonymous], INT J INFECT CONTR

[3]

[Anonymous], 2010, PERFORMANCE STANDARD

[4]

[Anonymous], 2011, Performance standards for antimicrobial disk susceptibility tests

[5]

approved standard M2-A11, V11th

[6]

[Anonymous], SPAN J CHEMOTHERAPY

[7]

Araj George F, 2012, J Med Liban, V60, P125

[8] ANTIMICROBIAL SUSCEPTIBILITY PATTERNS OF BACTERIAL ISOLATES AT THE AMERICAN-UNIVERSITY MEDICAL-CENTER IN LEBANON [J].

ARAJ, GF ;

UWAYDAH, MM ;

ALAMI, SY .

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1994, 20 (03) :151-158

[9] Prevalence of penicillin and erythromycin resistance among invasive Streptococcus pneumoniae isolates reported by laboratories in the southern and eastern Mediterranean region [J].

Borg, M. A. ;

Tiemersma, E. ;

Scicluna, E. ;

van de Sande-Bruinsma, N. ;

de Kraker, M. ;

Monen, J. ;

Grundmann, H. .

CLINICAL MICROBIOLOGY AND INFECTION, 2009, 15 (03) :232-237

[10] Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in invasive isolates from southern and eastern Mediterranean countries [J].

Borg, Michael A. ;

de Kraker, Marlieke ;

Scicluna, Elizabeth ;

van de Sande-Bruinsma, Nienke ;

Tiemersma, Edine ;

Monen, Jos ;

Grundmann, Hajo .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2007, 60 (06) :1310-1315

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