A decade of research into classical swine fever marker vaccine CP7_E2alf (Suvaxyn® CSF Marker): a review of vaccine properties

被引：31
作者：
Blome, Sandra [1 ]
Wernike, Kerstin [1 ]
Reimann, Ilona [1 ]
Koenig, Patricia [1 ]
Moss, Claudia [1 ]
Beer, Martin [1 ]
机构：
[1] Friedrich Loeffler Inst, Inst Diagnost Virol, Suedufer 10, D-17493 Greifswald, Germany
来源：
VETERINARY RESEARCH | 2017年 / 48卷
关键词：
LINKED-IMMUNOSORBENT-ASSAY; PRE-REGISTRATION EFFICACY; C-STRAIN VACCINE; CANDIDATE CP7-E2ALF; ORAL IMMUNIZATION; WILD BOAR; GENETIC DIFFERENTIATION; RT-PCR; VIRUS; CHALLENGE;
D O I：
10.1186/s13567-017-0457-y
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Due to its impact on animal health and pig industry, classical swine fever (CSF) is still one of the most important viral diseases of pigs. To control the disease, safe and highly efficacious live attenuated vaccines exist for decades. However, until recently, the available live vaccines did not allow a serological marker concept that is essentially important to circumvent long- term trade restrictions. In 2014, a new live attenuated marker vaccine, - Suvaxyn (R) CSF Marker (Zoetis), was licensed by the European Medicines Agency. This vaccine is based on pestivirus chimera "CP7_E2alf" that carries the main immunogen of CSF virus "Alfort/187", glycoprotein E2, in a bovine viral diarrhea virus type 1 backbone ("CP7"). This review summarizes the available data on design, safety, efficacy, marker diagnostics, and its possible integration into control strategies.
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页数：10
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