Smoking as a risk factor for dementia and cognitive decline: a meta-analysis of prospective studies

被引:614
作者
Anstey, Kaarin J.
von Sanden, Chwee
Salim, Agus
O'Kearney, Richard
机构
[1] Australian Natl Univ, Mental Hlth Res Ctr, Canberra, ACT 0200, Australia
[2] Australian Natl Univ, Sch Psychol, Canberra, ACT, Australia
关键词
Alzheimer disease; cognition; dementia; vascular; meta-analysis; smoking; ALZHEIMERS-DISEASE; FOLLOW-UP; INTERNATIONAL WORKSHOP; VASCULAR DEMENTIA; CIGARETTE-SMOKING; POPULATION; COHORT; IMPAIRMENT; HEALTH; DIAGNOSIS;
D O I
10.1093/aje/kwm116
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The authors assessed the association of smoking with dementia and cognitive decline in a meta-analysis of 19 prospective studies with at least 12 months of follow-up. Studies included a total of 26,374 participants followed for dementia for 2-30 years and 17,023 participants followed up for 2-7 years to assess cognitive decline. Mean study age was 74 years. Current smokers at baseline, relative to never smokers, had risks of 1.79 (95% confidence interval (Cl): 1.43, 2.23) for incident Alzheimer's disease, 1.78 (95% Cl: 1.28, 2.47) for incident vascular dementia, and 1.27 (95% Cl: 1.02, 1.60) for any dementia. Compared with those who never smoked, current smokers at baseline also showed greater yearly declines in Mini-Mental State Examination scores over the follow-up period (effect size (beta) = -0.13, 95% Cl: -0.18, -0.08). Compared with former smokers, current smokers at baseline showed an increased risk of Alzheimer's disease (relative risk = 1.70, 95% Cl: 1.25,2.31)and an increased decline in cognitive abilities (effect size (beta) = -0.07, 95% Cl: -0.11, -0.03), but the groups were not different regarding risk of vascular dementia or any dementia. The authors concluded that elderly smokers have increased risks of dementia and cognitive decline.
引用
收藏
页码:367 / 378
页数:12
相关论文
共 57 条
[1]   Smoking as a risk factor for Alzheimer's disease: contrasting evidence from a systematic review of case-control and cohort studies [J].
Almeida, OP ;
Hulse, GK ;
Lawrence, D ;
Flicker, L .
ADDICTION, 2002, 97 (01) :15-28
[2]  
[Anonymous], DIAG STAT MAN MENT D
[3]  
[Anonymous], 2005, COCHRANE LIB
[4]   Smoking cessation and cardiovascular disease risk factors: Results from the Third National Health and Nutrition Examination Survey [J].
Bakhru, A ;
Erlinger, TP .
PLOS MEDICINE, 2005, 2 (06) :528-536
[5]   Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers [J].
Beeri, MS ;
Rapp, M ;
Silverman, JM ;
Schmeidler, J ;
Grossman, HT ;
Fallon, JT ;
Purohit, DP ;
Perl, DP ;
Siddiqui, A ;
Lesser, G ;
Rosendorff, C ;
Haroutunian, V .
NEUROLOGY, 2006, 66 (09) :1399-1404
[6]   Relationship of race/ethnicity and blood pressure to change in cognitive function [J].
Bohannon, AD ;
Fillenbaum, GG ;
Pieper, CF ;
Hanlon, JT ;
Blazer, DG .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2002, 50 (03) :424-429
[7]   Smoking and the brain - No good evidence exists that smoking protects against dementia [J].
Brayne, C .
BRITISH MEDICAL JOURNAL, 2000, 320 (7242) :1087-1088
[8]   Health habits and risk of cognitive impairment and dementia in old age: A prospective study on the effects of exercise, smoking and alcohol consumption [J].
Broe, GA ;
Creasey, H ;
Jorm, AF ;
Bennett, HP ;
Casey, B ;
Waite, LM ;
Grayson, DA ;
Cullen, J .
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH, 1998, 22 (05) :621-623
[9]  
Bruno Richard S, 2006, Pathophysiology, V13, P143, DOI 10.1016/j.pathophys.2006.05.003
[10]   Smoking and drinking cessation and risk of esophageal cancer (Spain) [J].
Castellsagué, X ;
Muñoz, N ;
De Stefani, E ;
Victora, CG ;
Quintana, MJ ;
Castelletto, R ;
Rolón, PA .
CANCER CAUSES & CONTROL, 2000, 11 (09) :813-818