Chemically modified screen-printed electrodes as efficient potentiometric sensors for cyclobenzaprine hydrochloride determination in pure and pharmaceutical preparations

被引：0

作者：

Frag, Eman Y. ^{[1
]}

Mohamed, Marwa E. ^{[1
]}

Abdel Hameed, R. M. ^{[1
]}

Mahmoud, Asmaa M. ^{[1
]}

机构：

[1] Cairo Univ, Dept Chem, Fac Sci, Giza, Egypt

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2020年 / 34卷 / 03期

关键词：

alizarin red; cyclobenzaprine hydrochloride; modified screen printed electrode; potentiometric method; tricresylphosphate; MUSCLE SPASM; CARBON-PASTE; HUMAN PLASMA;

D O I：

10.1002/aoc.5439

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Chemically modified screen-printed electrodes (SPEs) with 3,4-dihydroxy-9,10-dioxo-2-anthracenesulfonic acid sodium salt [Alizarin Red (ALZ.R)] and tricresylphosphate (TCP) were fabricated and examined for potentiometric determination of cyclobenzaprine hydrochloride (CZP.HCl) in pure and pharmaceutical samples. The content of ALZ.R in the prepared SPEs varied, which significantly affected their potentiometric response during CZP.HCl estimation. The measured potential value was dependent on the pH of the studied solution. A stable modified SPE sensor was prepared with reproducible readings within 22 days. A wide linear concentration range could be measured with Nernestian slope value of 60.12 +/- 0.18 mV decade(-1). Based on the recorded analytical parameters of these modified SPEs, a sensitive and reliable detection of CZP.HCl in pharmaceutical samples could be attained.

引用

页数：7