ACYP2 polymorphisms are associated with the risk of liver cancer in a Han Chinese population

被引:0
作者
Chen, Zhong [1 ]
Sun, Yu [2 ]
Xu, Zhenxiong [2 ]
Xu, Junnv [3 ]
Li, Jingjie [4 ]
Yan, Mengdan [4 ]
Li, Jing [4 ]
Jin, Tianbo [4 ,5 ]
Lin, Haifeng [3 ]
机构
[1] Second Peoples Hosp Hainan Prov, Dept Thorac Surg, Wuzhishan 572200, Hainan, Peoples R China
[2] Second Peoples Hosp Hainan Prov, Dept Gen Surg, Wuzhishan 572200, Hainan, Peoples R China
[3] Agr Reclamat Gen Hosp Hainan Prov, Dept Internal Med Oncol, Haikou 570311, Hainan, Peoples R China
[4] Northwest Univ Xian, Key Lab Resource Biol & Biotechnol Western China, Minist Educ, Sch Life Sci, Xian 710069, Shaanxi, Peoples R China
[5] Xian Tiangen Precis Med Inst, Xian 710075, Shaanxi, Peoples R China
关键词
ACYP2; polymorphism; liver cancer; case-control; Han Chinese population; LEUKOCYTE TELOMERE LENGTH; GENOME-WIDE ASSOCIATION; HEPATOCELLULAR-CARCINOMA; GENETIC-VARIANTS; SUSCEPTIBILITY LOCUS; BREAST-CANCER; INSIGHTS; PATHOGENESIS;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We explored the association between single nucleotide polymorphisms (SNPs) in ACYP2 and liver cancer risk. Thirteen SNPs were genotyped in 473 cases and 564 controls. Genetic model, linkage disequilibrium, and haplotype analyses were performed to evaluate the association between ACPY2 SNPs and liver cancer risk. We found that rs6713088 (G allele: odds ratio [OR] = 1.27, 95% confidence interval [CI]: 1.07-1.52, P = 0.007; GG vs. CC: OR = 1.49, 95% CI: 1.02-2.1, P = 0.038), rs843711 (T allele: OR = 1.29, 95% CI: 1.09-1.54, P = 0.004; TT vs. CC: OR = 1.62, 95% CI: 1.13-2.31, P = 0.008), rs843706 (A allele: OR = 1.30, 95% CI: 1.09-1.55, P = 0.003; AA vs. CC: OR = 1.62, 95% CI: 1.13-2.31, P = 0.008), and rs843645 (GG vs. AG: OR = 1.40, 95% CI: 1.07-1.82, P = 0.014) were associated with an increased risk of liver cancer. In contrast, rs1682111 (A allele: OR = 0.77, 95% CI: 0.640-0.94, P = 0.007; AT vs. TT: OR = 0.69, 95% CI: 0.53-0.91, P = 0.007), rs843720 (additive model: OR = 0.82, 95% CI: 0.68-1.00, P = 0.049), ATATCGCC and CG haplotypes (OR = 0.76, 95% CI: 0.62-0.92, P = 0.006; OR = 0.78, 95% CI: 0.65-0.93, P = 0.006, respectively) were significantly decreased liver cancer risk. Our results confirmed that rs6713088, rs843645, rs843711 and rs843706 were significantly increased liver cancer risk, but rs1682111, rs843720 and haplotypes (ATATCGCC and CG) were significantly decreased liver cancer risk in a Han Chinese population.
引用
收藏
页码:67723 / 67731
页数:9
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