High percentage of seronegative HCV infections in hemodialysis patients:: The need for PCR

被引：38

作者：

Schröter, M ^{[1
]}

Feucht, HH ^{[1
]}

Schäfer, P ^{[1
]}

Zöllner, B ^{[1
]}

Laufs, R ^{[1
]}

机构：

[1] Univ Hamburg, Hosp Eppendorf, Inst Med Mikrobiol & Immunol, D-20246 Hamburg, Germany

来源：

INTERVIROLOGY | 1997年 / 40卷 / 04期

关键词：

hepatitis C virus; hepatitis C; hemodialysis; polymerase chain reaction; seroconversion;

D O I：

10.1159/000150558

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Among patients undergoing maintenance hemodialysis, a high prevalence of hepatitis C virus (HCV) infection can be observed. In a prospective study, sera of 273 patients were examined for the presence of HCV infection by serological tests and by PCR. Thirty-five patients (12.8%) were HCV antibody positive, and in 31 of them HCV RNA could be detected by PCR. Among the 238 seronegative patients HCV infection was detected in 12 cases (5.0%) exclusively by PCR. Only in 1 of these patients seroconversion could be observed within the 18-month follow-up period. These findings demonstrate that in hemodialysis patients PCR is necessary for the diagnosis of HCV infection.

引用

页码：277 / 278

页数：2

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