Induction of differentiation in human promyelocytic leukemia HL-60 cell line by niacin-related compounds

被引：24

作者：

Iwata, K ^{[1
]}

Ogata, S ^{[1
]}

Okumura, K ^{[1
]}

Taguchi, H ^{[1
]}

机构：

[1] Mie Univ, Fac Bioresources, Mol & Cellular Biol Lab, Dept Life Sci, Tsu, Mie 5148507, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2003年 / 67卷 / 05期

关键词：

niacin; isonicotinic acid; nicotinamide N-oxide; differentiation; HL-60;

D O I：

10.1271/bbb.67.1132

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Water-soluble vitamin, niacin, and its related compounds were examined for their differentiation-inducing activity in human promyelocytic leukemia cells (HL-60). Among the compounds, which inhibited cell proliferation measured by MTT assay, isonicotinic acid, nicotinamide N-oxide, and nicotinamide induced NBT reducing activity. HL-60 cells were differentiated into granulocyte-like cells by these compounds, judging from morphological changes and loss of nonspecific esterase activity. The differentiation-inducing activity of water-soluble vitamin and its related compounds suggest that these compounds may be applicable for medical use.

引用

页码：1132 / 1135

页数：4

共 24 条

[1] INDUCTION OF DIFFERENTIATION OF THE HUMAN PROMYELOCYTIC LEUKEMIA-CELL LINE (HL-60) BY RETINOIC ACID [J].

BREITMAN, TR ;

SELONICK, SE ;

COLLINS, SJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (05) :2936-2940

[2] MICROTITER ASSAY USEFUL FOR SCREENING OF CELL-DIFFERENTIATION AGENTS [J].

CATINO, JJ ;

MICELI, LA .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1988, 80 (12) :962-966

[3]

CLAPPER DL, 1987, J BIOL CHEM, V262, P9561

[4] TERMINAL DIFFERENTIATION OF HUMAN PROMYELOCYTIC LEUKEMIA-CELLS INDUCED BY DIMETHYL-SULFOXIDE AND OTHER POLAR COMPOUNDS [J].

COLLINS, SJ ;

RUSCETTI, FW ;

GALLAGHER, RE ;

GALLO, RC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (05) :2458-2462

[5] A QUICK AND SIMPLE METHOD FOR THE QUANTITATION OF LACTATE-DEHYDROGENASE RELEASE IN MEASUREMENTS OF CELLULAR CYTO-TOXICITY AND TUMOR NECROSIS FACTOR (TNF) ACTIVITY [J].

DECKER, T ;

LOHMANNMATTHES, ML .

JOURNAL OF IMMUNOLOGICAL METHODS, 1988, 115 (01) :61-69

[6] USE OF ALL-TRANS RETINOIC ACID IN THE TREATMENT OF ACUTE PROMYELOCYTIC LEUKEMIA [J].

HUANG, ME ;

YE, YC ;

CHEN, SR ;

CHAI, JR ;

LU, JX ;

ZHOA, L ;

GU, LJ ;

WANG, ZY .

BLOOD, 1988, 72 (02) :567-572

[7]

HUGHES HB, 1953, J PHARMACOL EXP THER, V106, P444

[8] INVOLVEMENT OF LIVER ALDEHYDE OXIDASE IN THE REDUCTION OF NICOTINAMIDE N-OXIDE [J].

KITAMURA, S ;

TATSUMI, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (02) :602-606

[9] INVOLVEMENT OF OXYGEN RADICALS IN THE DIFFERENTIATION OF RAT MYELOMONOCYTIC LEUKEMIA-CELLS IN-VITRO AND IN-VIVO [J].

KOBAYASHI, M ;

NISHIHARA, J ;

FUJII, Y ;

MAEDA, H ;

HOSOKAWA, M ;

TAKEICHI, N .

LEUKEMIA RESEARCH, 1994, 18 (03) :199-203

[10]

KOEFFLER HP, 1983, BLOOD, V62, P709

← 1 2 3 →