Inflammation negatively correlates with amygdala-ventromedial prefrontal functional connectivity in association with anxiety in patients with depression: Preliminary results
被引:72
作者:
Mehta, Neeti D.
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Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA
Emory Univ, Sch Med, Grad Div Biol & Biomed Sci, Grad Program Neurosci, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA
Mehta, Neeti D.
[1
,2
]
Haroon, Ebrahim
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Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA
Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA
Haroon, Ebrahim
[1
,3
]
Xu, Xiaodan
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h-index: 0
机构:
Shenzhen Univ, Sch Psychol & Sociol, Shenzhen 518060, Guangdong, Peoples R China
Shenzhen Univ, Shenzhen Key Lab Affect & Social Cognit Sci, Shenzhen 518060, Guangdong, Peoples R ChinaEmory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA
Xu, Xiaodan
[4
,5
]
Woolwine, Bobbi J.
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Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA
Woolwine, Bobbi J.
[1
]
Li, Zhihao
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Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA
Shenzhen Univ, Sch Psychol & Sociol, Shenzhen 518060, Guangdong, Peoples R China
Shenzhen Univ, Shenzhen Key Lab Affect & Social Cognit Sci, Shenzhen 518060, Guangdong, Peoples R ChinaEmory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA
Li, Zhihao
[1
,4
,5
]
Felger, Jennifer C.
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Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA
Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USAEmory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA
Felger, Jennifer C.
[1
,3
]
机构:
[1] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA
[2] Emory Univ, Sch Med, Grad Div Biol & Biomed Sci, Grad Program Neurosci, Atlanta, GA 30322 USA
[3] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA
[4] Shenzhen Univ, Sch Psychol & Sociol, Shenzhen 518060, Guangdong, Peoples R China
[5] Shenzhen Univ, Shenzhen Key Lab Affect & Social Cognit Sci, Shenzhen 518060, Guangdong, Peoples R China
Biomarkers of inflammation, including inflammatory cytokines and the acute-phase reactant C-reactive protein (CRP), are reliably increased in a subset of patients with depression, anxiety disorders and post-traumatic stress disorder (PTSD). Administration of innate immune stimuli to laboratory subjects and the associated release of inflammatory cytokines has been shown to affect brain regions involved in fear, anxiety and emotional processing such as the amygdala. However, the role of inflammation in altered circuitry involving amygdala and other brain regions and its subsequent contribution to symptom severity in depression, anxiety disorders and PTSD is only beginning to be explored. Herein, medically-stable, currently urnnedicated outpatients with a primary diagnosis of major depressive disorder (MDD; n = 48) underwent resting-state functional MRI (rfMRI) to determine whether altered connectivity between the amygdala and whole brain was observed in a subset of patients with high inflammation and symptoms of anxiety. Whole-brain, voxel-wise functional connectivity analysis of the right and left amygdala as a function of inflammation (plasma CRP concentrations) revealed that increased CRP predicted decreased functional connectivity between right amygdala and left ventromedial prefrontal cortex (vmPFC) (corrected p < 0.05). Amygdala-vmPFC connectivity was, in turn, negatively correlated with symptoms of anxiety (r = 0.33, df = 46, p = 0.022). In exploratory analyses, relationships between low amygdala-vmPFC connectivity and high anxiety were only observed in patients with a secondary diagnosis of an anxiety disorder or PTSD (r = 0.54 to 0.87, p < 0.05). More work is needed to understand the role of inflammation and its effects on amygdala-vmPFC circuitry and symptoms of anxiety in MDD patients with co morbid anxiety disorders or PTSD.
机构:
Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, EnglandKings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England
Danese, Andrea
;
Moffitt, Terrie E.
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England
Duke Univ, Dept Psychol, Durham, NC USA
Duke Univ, Dept Neurosci, Durham, NC USA
Duke Univ, Dept Psychiat & Behav Sci, Durham, NC USA
Duke Univ, Inst Genome Sci & Policy, Durham, NC USAKings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England
Moffitt, Terrie E.
;
Pariante, Carmine M.
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h-index: 0
机构:
Kings Coll London, Inst Psychiat, Dept Med Psychol, London SE5 8AF, EnglandKings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England
Pariante, Carmine M.
;
Ambler, Antony
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h-index: 0
机构:
Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, EnglandKings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England
Ambler, Antony
;
Poulton, Richie
论文数: 0引用数: 0
h-index: 0
机构:
Univ Otago, Dunedin Sch Med, Dunedin, New ZealandKings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England
Poulton, Richie
;
Caspi, Avshalom
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England
Duke Univ, Dept Psychol, Durham, NC USA
Duke Univ, Dept Neurosci, Durham, NC USA
Duke Univ, Dept Psychiat & Behav Sci, Durham, NC USA
Duke Univ, Inst Genome Sci & Policy, Durham, NC USAKings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England
机构:
Univ Calif Los Angeles, Dept Psychol, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychol, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USA
Eisenberger, Naomi I.
;
Berkman, Elliot T.
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h-index: 0
机构:
Univ Oregon, Dept Psychol, Eugene, OR 97403 USAUniv Calif Los Angeles, Dept Psychol, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USA
Berkman, Elliot T.
;
Inagaki, Tristen K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Psychol, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychol, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USA
Inagaki, Tristen K.
;
Rameson, Lian T.
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h-index: 0
机构:
Univ Calif Los Angeles, Dept Psychol, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychol, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USA
Rameson, Lian T.
;
Mashal, Nehjla M.
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h-index: 0
机构:
Northwestern Univ, Dept Psychol, Evanston, IL USAUniv Calif Los Angeles, Dept Psychol, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USA
Mashal, Nehjla M.
;
Irwin, Michael R.
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h-index: 0
机构:
Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychol, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USA
机构:
Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA
Vet Affairs VA San Diego Healthcare Syst, San Diego, CA USAUniv Calif San Diego, Dept Med, San Diego, CA 92103 USA
Eraly, Satish A.
;
Nievergelt, Caroline M.
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h-index: 0
机构:
Vet Affairs VA San Diego Healthcare Syst, San Diego, CA USA
VA Ctr Excellence Stress & Mental Hlth, San Diego, CA USA
UCSD, Dept Psychiat, La Jolla, CA USAUniv Calif San Diego, Dept Med, San Diego, CA 92103 USA
Nievergelt, Caroline M.
;
Maihofer, Adam X.
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h-index: 0
机构:
UCSD, Dept Psychiat, La Jolla, CA USAUniv Calif San Diego, Dept Med, San Diego, CA 92103 USA
Maihofer, Adam X.
;
Barkauskas, Donald A.
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h-index: 0
机构:
Univ So Calif, Dept Prevent Med, Los Angeles, CA 90089 USAUniv Calif San Diego, Dept Med, San Diego, CA 92103 USA
Barkauskas, Donald A.
;
Biswas, Nilima
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h-index: 0
机构:
Univ Calif San Diego, Dept Med, San Diego, CA 92103 USAUniv Calif San Diego, Dept Med, San Diego, CA 92103 USA
Biswas, Nilima
;
Agorastos, Agorastos
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Univ Med Ctr Hamburg Eppendorf, Dept Psychiat & Psychotherapy, Hamburg, GermanyUniv Calif San Diego, Dept Med, San Diego, CA 92103 USA
Agorastos, Agorastos
;
O'Connor, Daniel T.
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h-index: 0
机构:
Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA
Vet Affairs VA San Diego Healthcare Syst, San Diego, CA USAUniv Calif San Diego, Dept Med, San Diego, CA 92103 USA
O'Connor, Daniel T.
;
Baker, Dewleen G.
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h-index: 0
机构:
Vet Affairs VA San Diego Healthcare Syst, San Diego, CA USA
VA Ctr Excellence Stress & Mental Hlth, San Diego, CA USA
UCSD, Dept Psychiat, La Jolla, CA USAUniv Calif San Diego, Dept Med, San Diego, CA 92103 USA
机构:
Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, EnglandKings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England
Danese, Andrea
;
Moffitt, Terrie E.
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England
Duke Univ, Dept Psychol, Durham, NC USA
Duke Univ, Dept Neurosci, Durham, NC USA
Duke Univ, Dept Psychiat & Behav Sci, Durham, NC USA
Duke Univ, Inst Genome Sci & Policy, Durham, NC USAKings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England
Moffitt, Terrie E.
;
Pariante, Carmine M.
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll London, Inst Psychiat, Dept Med Psychol, London SE5 8AF, EnglandKings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England
Pariante, Carmine M.
;
Ambler, Antony
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h-index: 0
机构:
Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, EnglandKings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England
Ambler, Antony
;
Poulton, Richie
论文数: 0引用数: 0
h-index: 0
机构:
Univ Otago, Dunedin Sch Med, Dunedin, New ZealandKings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England
Poulton, Richie
;
Caspi, Avshalom
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England
Duke Univ, Dept Psychol, Durham, NC USA
Duke Univ, Dept Neurosci, Durham, NC USA
Duke Univ, Dept Psychiat & Behav Sci, Durham, NC USA
Duke Univ, Inst Genome Sci & Policy, Durham, NC USAKings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England
机构:
Univ Calif Los Angeles, Dept Psychol, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychol, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USA
Eisenberger, Naomi I.
;
Berkman, Elliot T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Oregon, Dept Psychol, Eugene, OR 97403 USAUniv Calif Los Angeles, Dept Psychol, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USA
Berkman, Elliot T.
;
Inagaki, Tristen K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Psychol, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychol, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USA
Inagaki, Tristen K.
;
Rameson, Lian T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Psychol, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychol, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USA
Rameson, Lian T.
;
Mashal, Nehjla M.
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Dept Psychol, Evanston, IL USAUniv Calif Los Angeles, Dept Psychol, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USA
Mashal, Nehjla M.
;
Irwin, Michael R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychol, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USA
机构:
Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA
Vet Affairs VA San Diego Healthcare Syst, San Diego, CA USAUniv Calif San Diego, Dept Med, San Diego, CA 92103 USA
Eraly, Satish A.
;
Nievergelt, Caroline M.
论文数: 0引用数: 0
h-index: 0
机构:
Vet Affairs VA San Diego Healthcare Syst, San Diego, CA USA
VA Ctr Excellence Stress & Mental Hlth, San Diego, CA USA
UCSD, Dept Psychiat, La Jolla, CA USAUniv Calif San Diego, Dept Med, San Diego, CA 92103 USA
Nievergelt, Caroline M.
;
Maihofer, Adam X.
论文数: 0引用数: 0
h-index: 0
机构:
UCSD, Dept Psychiat, La Jolla, CA USAUniv Calif San Diego, Dept Med, San Diego, CA 92103 USA
Maihofer, Adam X.
;
Barkauskas, Donald A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ So Calif, Dept Prevent Med, Los Angeles, CA 90089 USAUniv Calif San Diego, Dept Med, San Diego, CA 92103 USA
Barkauskas, Donald A.
;
Biswas, Nilima
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Med, San Diego, CA 92103 USAUniv Calif San Diego, Dept Med, San Diego, CA 92103 USA
Biswas, Nilima
;
Agorastos, Agorastos
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med Ctr Hamburg Eppendorf, Dept Psychiat & Psychotherapy, Hamburg, GermanyUniv Calif San Diego, Dept Med, San Diego, CA 92103 USA
Agorastos, Agorastos
;
O'Connor, Daniel T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA
Vet Affairs VA San Diego Healthcare Syst, San Diego, CA USAUniv Calif San Diego, Dept Med, San Diego, CA 92103 USA
O'Connor, Daniel T.
;
Baker, Dewleen G.
论文数: 0引用数: 0
h-index: 0
机构:
Vet Affairs VA San Diego Healthcare Syst, San Diego, CA USA
VA Ctr Excellence Stress & Mental Hlth, San Diego, CA USA
UCSD, Dept Psychiat, La Jolla, CA USAUniv Calif San Diego, Dept Med, San Diego, CA 92103 USA