Relevance of ABC Transporters in Drug Development

被引：11

作者：

Nwabufo, Chukwunonso K. ^{[1
,2
]}

机构：

[1] Univ Saskatchewan, Coll Pharm & Nutr, Drug Discovery & Dev Res Grp, Saskatoon, SK, Canada

[2] Univ Toronto, Leslie Dan Fac Pharm, Dept Pharmaceut Sci, Toronto, ON M5S 3M2, Canada

来源：

CURRENT DRUG METABOLISM | 2022年 / 23卷 / 06期

关键词：

P-glycoprotein; multidrug resistance-associated protein 2; breast cancer resistance protein; drug development; pharmacokinetics; pharmacodynamics; CANCER RESISTANCE PROTEIN; BLOOD-BRAIN-BARRIER; BINDING CASSETTE TRANSPORTERS; PRODUCT P-GLYCOPROTEIN; MULTIDRUG-RESISTANCE; ORAL BIOAVAILABILITY; INCREASED SENSITIVITY; EFFLUX TRANSPORTERS; STEM-CELLS; FUNCTIONAL-CHARACTERIZATION;

D O I：

10.2174/1389200223666220621113524

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ATP-binding cassette (ABC) transporters play a critical role in protecting vital organs such as the brain and placenta against xenobiotics, as well as in modulating the pharmacological and toxicological profile of several drug candidates by restricting their penetration through cellular and tissue barriers. This review paper describes the structure and function of ABC transporters as well as the role of P-glycoprotein, multidrug resistance-associated protein 2 and breast cancer resistance protein in the disposition of drugs. Furthermore, a review of the in vitro and in vivo techniques for evaluating the interaction between drugs and ABC transporters is provided.

引用

页码：434 / 446

页数：13

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