Serum measurements of testosterone, insulin-like growth factor 1, and insulin-like growth factor binding protein-3 in the diagnosis of prostate cancer among Korean men

被引：13
作者：
Hong, Sung Kyu [1 ]
Han, Byung Kyu [1 ]
Jeong, Jae Seung [1 ]
Jeong, Seong Jin [1 ]
Moon, Ki Hyuk [1 ]
Byun, Seok Soo [1 ]
Lee, Sang Eun [1 ]
机构：
[1] Seoul Natl Univ Bundang Hosp, Dept Urol, Kyonggi Do 463707, South Korea
来源：
ASIAN JOURNAL OF ANDROLOGY | 2008年 / 10卷 / 02期
关键词：
prostate; prostate cancer; testosterone; insulin-like growth factor; insulin-like growth factor-binding protein-3;
D O I：
10.1111/j.1745-7262.2008.00296.x
中图分类号：
R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
摘要：
Aim: To investigate the relationships of serum testosterone, insulin-like growth factor (IGF)-1 and IGF-binding protein (IGFBP)-3 levels with prostate cancer risk and also with known prognostic parameters of prostate cancer in Korean men who received radical retropubic prostatectomy (RRP) for clinically-localized prostate cancer. Methods: Serum levels of total testosterone, free testosterone, IGF-1 and IGFBP-3 were determined in 592 patients who subsequently received prostate biopsy. Results were compared between patients who eventually received RRP for prostate cancer (n = 159) and those who were not diagnosed with prostate cancer from biopsy (control group, n = 433). Among the prostate cancer only patients, serum hormonal levels obtained were analyzed in relation to serum prostate specific antigen (PSA), pathological T stage and pathological Gleason score. Results: Prostate cancer patients and the control group demonstrated no significant differences regarding serum levels of total testosterone, free testosterone, IGF-1 and IGFBP-3 across the different age groups. Among the cancer only patients, no significant associations were observed for serum levels of total testosterone, free testosterone, IGF-1 and IGFBP-3 levels with pathological T stage, pathological Gleason score and preoperative PSA. Conclusion: Our data indicate that simple quantifications of serum testosterone and IGF-1 along with IGFBP-3 levels might not provide useful clinical information in the diagnosis of clinically localized prostate cancer in Korean men. Also, our results suggest that serum levels of testosterone, IGF-1 and IGFBP-3 might not be significantly associated with known prognostic factors of clinically localized prostate cancer in Korean men.
引用
收藏
页码：207 / 213
页数：7
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