Transcription in kinetoplastid protozoa: why be normal?

被引：124
作者：
Campbell, DA [1 ]
Thomas, S [1 ]
Sturm, NR [1 ]
机构：
[1] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA
来源：
MICROBES AND INFECTION | 2003年 / 5卷 / 13期
关键词：
Leishmania; polycistronic; promoter; transcription factor; trans splicing; Trypanosoma;
D O I：
10.1016/j.micinf.2003.09.005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Transcription in the kinetoplastid protozoa shows substantial variation from the paradigms of eukaryotic gene expression, including polycistronic transcription, a paucity of RNA polymerase (RNAP) 11 promoters, no qualitative regulated transcription initiation for most protein-coding genes, transcription of some protein-coding genes by RNAP 1, an exclusive subnuclear location for VSG transcription, the dependence of small nuclear RNA gene transcription on an upstream tRNA gene, and the synthesis of mitochondrial tRNAs in the nucleus. Here, we present a broad overview of what is known about transcription in the kinetoplastids and what has yet to be determined. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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页码：1231 / 1240
页数：10
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