Catalytic enantioselective arylative cyclizations of alkynyl 1,3-diketones by 1,4-rhodium(i) migration

被引：25

作者：

Groves, Alistair ^{[1
,2
]}

Sun, Jinwei ^{[1
,2
,3
]}

Parke, Hal R. I. ^{[1
,2
]}

Callingham, Michael ^{[1
,2
]}

Argent, Stephen P. ^{[2
]}

Taylor, Laurence J. ^{[2
]}

Lam, Hon Wai ^{[1
,2
]}

机构：

[1] Univ Nottingham, GlaxoSmithKline Carbon Neutral Labs Sustainable C, Jubilee Campus,Triumph Rd, Nottingham NG7 2TU, England

[2] Univ Nottingham, Sch Chem, Univ Pk, Nottingham NG7 2RD, England

[3] Nanjing Univ Informat Sci & Technol, Jiangsu Collaborat Innovat Ctr Atmospher Environm, Jiangsu Key Lab Atmospher Environm Monitoring & P, Sch Chem & Mat Sci, Nanjing 210044, Jiangsu, Peoples R China

来源：

CHEMICAL SCIENCE | 2020年 / 11卷 / 10期

基金：

英国工程与自然科学研究理事会;

关键词：

REMOTE FUNCTIONALIZATION; C-C; ARYLBORONIC ACIDS; RHODIUM; ISOMERIZATION; ALLYLATION; 1,3-ENYNES; COMPLEXES; EFFICIENT; REAGENTS;

D O I：

10.1039/c9sc06309a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enantioselective synthesis of densely functionalized polycarbocycles by the rhodium(i)-catalyzed reaction of arylboronic acids with 1,3-diketones is described. The key step in these desymmetrizing domino addition-cyclization reactions is an alkenyl-to-aryl 1,4-Rh(i) migration, which enables arylboronic acids to function effectively as 1,2-dimetalloarene surrogates.

引用

收藏

页码：2759 / 2764

页数：6

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