Controversial issues in the management of older adults with early breast cancer

被引：9

作者：

Mislang, Anna Rachelle ^{[1
]}

Cheung, Kwok-Leung ^{[2
]}

Hamaker, Marije E. ^{[3
]}

Kunkler, Ian ^{[4
]}

Markopoulos, Christos ^{[5
]}

Orecchia, Roberto ^{[6
,7
]}

Brain, Etienne ^{[8
]}

Biganzoli, Laura ^{[1
]}

机构：

[1] Nuovo Osped Santo Stefano, Inst Toscano Tumori, Med Oncol Dept, I-59100 Prato, Italy

[2] Univ Nottingham, Sch Med, Nottingham, England

[3] Diakonessenhuis Utrecht Zeist, Dept Geriatr Med, Utrecht, Netherlands

[4] Univ Edinburgh, Western Gen Hosp, Edinburgh Canc Res Ctr, Edinburgh EH4 2XU, Midlothian, Scotland

[5] Natl & Kapodistrian Univ Athens, Dept Surg, Med Sch, Athens 11527, Greece

[6] European Inst Oncol, Milan, Italy

[7] Univ Milan, Milan, Italy

[8] Hop Rene Huguenin, Inst Curie, Dept Med Oncol, St Cloud, France

来源：

JOURNAL OF GERIATRIC ONCOLOGY | 2017年 / 8卷 / 06期

关键词：

Older adults; Early breast cancer; Surgery; Radiotherapy; Chemotherapy; Geriatric assessment; NO AXILLARY DISSECTION; INTERNATIONAL EXPERT CONSENSUS; CLINICAL-PRACTICE GUIDELINES; LUMPECTOMY PLUS TAMOXIFEN; ADJUVANT CHEMOTHERAPY; FOLLOW-UP; CONSERVING SURGERY; SENTINEL-NODE; LOCAL-CONTROL; OPEN-LABEL;

D O I：

10.1016/j.jgo.2017.05.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

It is well recognized that the incidence of breast cancer increases significantly with age. Despite this, older people remain under-represented in many clinical trials and their management relies on extrapolation of data from younger patients. Providing an aggressive intervention can be challenging, particularly in less fit older patients where a conservative approach is commonly perceived to be more appropriate. The optimal management of this population is unknown and treatment decision should be personalized. This review article will discuss several controversial issues in managing older adults with early breast cancer in a multidisciplinary setting, including the role of surgical treatment of the axilla in clinically node negative disease, radiotherapy after breast conservation surgery in low-risk tumours, personalizing adjuvant systemic therapy, and geriatric assessments in breast cancer treatment decisions. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：397 / 402

页数：6

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