Restoration of Useful Vision up to Letter Recognition Capabilities Using Subretinal Microphotodiodes

被引：28

作者：

Benav, Heval ^{[1
]}

Bartz-Schmidt, Karl U. ^{[2
]}

Besch, Dorothea ^{[2
]}

Bruckmann, Anna ^{[2
]}

Gekeler, Florian ^{[2
]}

Greppmaier, Udo ^{[3
]}

Harscher, Alex ^{[3
]}

Kibbel, Steffen ^{[3
]}

Kusnyerik, Akos ^{[4
]}

Peters, Tobias ^{[5
]}

Sachs, Helmut ^{[6
]}

Stett, Alfred ^{[7
]}

Stingl, Katarina ^{[2
]}

Wilhelm, Barbara ^{[5
]}

Wilke, Robert ^{[2
]}

Wrobel, Walter ^{[3
]}

Zrenner, Eberhart ^{[8
]}

机构：

[1] Frondsbergstr 23, D-72070 Tubingen, Germany

[2] Univ Tubingen, Ctr Ophthalmol, Tubingen, Germany

[3] Retina Implant AG, Reutlingen, Germany

[4] Semmelweis Univ, Dept Ophthalmol, Budapest, Hungary

[5] Univ Tubingen, Steinbeis Transfer Centre Autonomous Nervous Syst, Ofterdingen, Germany

[6] Klinikum Friedrichstadt, Dresden, Germany

[7] Univ Tubingen, Nat & Med Sci Inst, Reutlingen, Germany

[8] Univ Tubingen, Dept Ophthalm Res, Pathophysiol Vis, D-72076 Tubingen, Germany

来源：

2010 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) | 2010年

关键词：

VISUAL PROSTHESIS; IMPLANTATION; ELECTRODES; STIMULATION;

D O I：

10.1109/IEMBS.2010.5627549

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Our group has developed a subretinal microphotodiode array for restoration of vision. In a clinical pilot study the array has been implanted in 11 patients suffering from photoreceptor degenerations. Here we present promising results from some of those patients where the retinal tissue above the chip was functional and the implant fulfilled its expected function. A spatial resolution of approximately 0.3 cycles/degree could be achieved with fine stripe patterns. In one subject where the implant had been placed directly under the macular region of the retina a visual acuity of 20/1000 could be measured. Artificially restored visual acuity of this quality has not been reported previously. Finally, we present images illustrating an approximation of how the visual perceptions might have appeared to the subjects, based on a mathematical model and patient reports.

引用

页码：5919 / 5922

页数：4

共 15 条

[1]

[Anonymous], 2009, INVEST OPHTHALMOL VI

[2]

Benav H., 2009, ARVO M ABSTR, V50, P4593

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