Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China

被引：1551

作者：

Wu, Aiping ^{[1
,2
,8
]}

Peng, Yousong ^{[3
]}

Huang, Baoying ^{[4
]}

Ding, Xiao ^{[1
,2
,8
]}

Wang, Xianyue ^{[1
,2
,8
]}

Niu, Peihua ^{[4
]}

Meng, Jing ^{[1
,2
,8
]}

Zhu, Zhaozhong ^{[3
]}

Zhang, Zheng ^{[3
]}

Wang, Jiangyuan ^{[1
,2
,8
]}

Sheng, Jie ^{[1
,2
,8
]}

Quan, Lijun ^{[5
]}

Xia, Zanxian ^{[6
,9
,10
]}

Tan, Wenjie ^{[4
]}

Cheng, Genhong ^{[7
]}

Jiang, Taijiao ^{[1
,2
,8
]}

机构：

[1] Chinese Acad Med Sci, Inst Basic Med Sci, Ctr Syst Med, Beijing 100005, Peoples R China

[2] Peking Union Med Coll, Beijing 100005, Peoples R China

[3] Hunan Univ, Hunan Prov Key Lab Med Virol, Coll Biol, Changsha 410082, Peoples R China

[4] China CDC, Natl Inst Viral Dis Control & Prevent, Natl Hlth & Family Planning Commiss, Key Lab Med Virol, Beijing 102206, Peoples R China

[5] Soochow Univ, Sch Comp Sci & Technol, Suzhou, Peoples R China

[6] Cent South Univ, Sch Life Sci, Dept Cell Biol, Changsha 410013, Peoples R China

[7] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

[8] Suzhou Inst Syst Med, Suzhou 215123, Jiangsu, Peoples R China

[9] Cent South Univ, Sch Life Sci, Hunan Key Lab Med Genet, Hunan Key Lab Anim Models Human Dis, Changsha 410013, Peoples R China

[10] Cent South Univ, Sch Life Sci, Ctr Med Genet, Changsha 410013, Peoples R China

来源：

CELL HOST & MICROBE | 2020年 / 27卷 / 03期

基金：

中国国家自然科学基金;

关键词：

RECEPTOR;

D O I：

10.1016/j.chom.2020.02.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses. A systematic comparison identified 380 amino acid substitutions between these coronaviruses, which may have caused functional and pathogenic divergence of 2019-nCoV.

引用

页码：325 / 328

页数：4

共 14 条

[1]

[Anonymous], VIRUSES

[2]

*CHIN CDC, 2020, TRACK EP

[3] Origin and evolution of pathogenic coronaviruses [J].

Cui, Jie ;

Li, Fang ;

Shi, Zheng-Li .

NATURE REVIEWS MICROBIOLOGY, 2019, 17 (03) :181-192

[4] Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor [J].

Ge, Xing-Yi ;

Li, Jia-Lu ;

Yang, Xing-Lou ;

Chmura, Aleksei A. ;

Zhu, Guangjian ;

Epstein, Jonathan H. ;

Mazet, Jonna K. ;

Hu, Ben ;

Zhang, Wei ;

Peng, Cheng ;

Zhang, Yu-Ji ;

Luo, Chu-Ming ;

Tan, Bing ;

Wang, Ning ;

Zhu, Yan ;

Crameri, Gary ;

Zhang, Shu-Yi ;

Wang, Lin-Fa ;

Daszak, Peter ;

Shi, Zheng-Li .

NATURE, 2013, 503 (7477) :535-+

[5] Isolation and characterization of viruses related to the SARS coronavirus from animals in Southern China [J].

Guan, Y ;

Zheng, BJ ;

He, YQ ;

Liu, XL ;

Zhuang, ZX ;

Cheung, CL ;

Luo, SW ;

Li, PH ;

Zhang, LJ ;

Guan, YJ ;

Butt, KM ;

Wong, KL ;

Chan, KW ;

Lim, W ;

Shortridge, KF ;

Yuen, KY ;

Peiris, JSM ;

Poon, LLM .

SCIENCE, 2003, 302 (5643) :276-278

[6] SARS corona virus peptides recognized by antibodies in the sera of convalescent cases [J].

Guo, JP ;

Petric, M ;

Campbell, W ;

McGeer, PL .

VIROLOGY, 2004, 324 (02) :251-256

[7] Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [J].

Huang, Chaolin ;

Wang, Yeming ;

Li, Xingwang ;

Ren, Lili ;

Zhao, Jianping ;

Hu, Yi ;

Zhang, Li ;

Fan, Guohui ;

Xu, Jiuyang ;

Gu, Xiaoying ;

Cheng, Zhenshun ;

Yu, Ting ;

Xia, Jiaan ;

Wei, Yuan ;

Wu, Wenjuan ;

Xie, Xuelei ;

Yin, Wen ;

Li, Hui ;

Liu, Min ;

Xiao, Yan ;

Gao, Hong ;

Guo, Li ;

Xie, Jungang ;

Wang, Guangfa ;

Jiang, Rongmeng ;

Gao, Zhancheng ;

Jin, Qi ;

Wang, Jianwei ;

Cao, Bin .

LANCET, 2020, 395 (10223) :497-506

[8] CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus [J].

Jeffers, SA ;

Tusell, SM ;

Gillim-Ross, L ;

Hemmila, EM ;

Achenbach, JE ;

Babcock, GJ ;

Thomas, WD ;

Thackray, LB ;

Young, MD ;

Mason, RJ ;

Ambrosino, DM ;

Wentworth, DE ;

DeMartini, JC ;

Holmes, KV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (44) :15748-15753

[9] Structure, Function, and Evolution of Coronavirus Spike Proteins [J].

Li, Fang .

ANNUAL REVIEW OF VIROLOGY, VOL 3, 2016, 3 :237-261

[10] Evidence for Camel-to-Human Transmission of MERS Coronavirus [J].

Drosten, Christian ;

Kellam, Paul ;

Memish, Ziad A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (14) :1359-1360

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