A facile preparation and crystal structure of romipeptide A

被引：0

作者：

Zhang, Hui ^{[1
,2
]}

Qi, Huan ^{[3
]}

Duan, Wen-kai ^{[2
]}

Zhang, Ji ^{[1
]}

Wang, Ji-dong ^{[3
]}

Xiang, Wen-sheng ^{[1
]}

机构：

[1] Northeast Agr Univ, Sch Life Sci, Life Sci & Biotechnol Res Ctr, Harbin 150030, Peoples R China

[2] Taizhou Vocat Coll Sci & Technol, Taizhou 318000, Peoples R China

[3] Huzhou Univ, Coll Life Sci, Key Lab Vector Biol & Pathogen Control Zhejiang P, Huzhou 313000, Peoples R China

来源：

JOURNAL OF ANTIBIOTICS | 2022年 / 75卷 / 01期

关键词：

DEPSIPEPTIDE; FK228;

D O I：

10.1038/s41429-021-00487-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A double disulfide tethering depsipeptide dimer, romipeptide A (1) was prepared by NaOH catalyzed dimerization of romidepsin. Its structure was determined by analysis of NMR and HR-ESI-MS data as well as single crystal X-ray diffraction. Bioassay results showed that 1 exhibited good cytotoxic activity against two tumor cell lines B16 and HCT116. This study reported the single crystal data of 1 for the first time. The facile preparation of 1 afforded enough amount for its further biological evaluations.

引用

页码：48 / 50

页数：3

共 4 条

[1] Structure of Hormaomycin, a Naturally Occurring Cyclic Octadepsipeptide, in the Crystal
Gruene, Tim
Sheldricle, George M.
ZlatopolsIdybe, Boris D.
Kozhushkovb, Sergei I.
de Meijereb, Armin
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2014, 69 (9-10): : 945 - 949
[2] Crystal structure of a depsipeptide, Boc-(Leu-Leu-Lac)3-Leu-Leu-OEt
Ohyama, T
Oku, H
Yoshida, M
Katakai, R
BIOPOLYMERS, 2001, 58 (07) : 636 - 642
[3] Antineoplastic Agents. 590. X-ray Crystal Structure of Dolastatin 16 and Syntheses of the Dolamethylleuine and Dolaphenvaline Units
Pettit, George R.
Smith, Thomas H.
Xu, Jun-Ping
Herald, Delbert L.
Flahive, Erik J.
Anderson, Collin R.
Belcher, Paul E.
Knight, John C.
JOURNAL OF NATURAL PRODUCTS, 2011, 74 (05): : 1003 - 1008
[4] Addition of a peptide fragment on an a-helical depsipeptide induces α/310-conjugated helix:: Synthesis, crystal structure, and CD spectra of Boc-Leu-Leu-Ala-(Leu-Leu-LaC)3-Leu-Leu-OEt
Oku, H
Ohyama, T
Hiroki, A
Yamada, K
Fukuyama, K
Kawaguchi, H
Katakai, R
BIOPOLYMERS, 2004, 75 (03) : 242 - 254

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