Short-term treatment with prostaglandin E1 analogue has long-term preventive effects on intimal thickening in balloon-injured rat carotid arteries

被引：4

作者：

Shimauchi, A ^{[1
]}

Toki, Y ^{[1
]}

Numaguchi, Y ^{[1
]}

Mukawa, H ^{[1
]}

Matsui, H ^{[1
]}

Okumura, K ^{[1
]}

Ito, T ^{[1
]}

Hayakawa, T ^{[1
]}

机构：

[1] Nagoya Univ, Sch Med, Nagoya, Aichi 4668550, Japan

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 1998年 / 56卷 / 2-3期

关键词：

intimal thickening; balloon injury; prostaglandin E-1 analogue; alprostadil; rat carotid arteries;

D O I：

10.1016/S0090-6980(98)00047-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examined effects of a prostaglandin E-1 analogue alprostadil on intimal thickening and arterial remodeling in balloon-injured rat carotid arteries. Right common carotid arteries were balloon-injured, and their left counterparts were sham-operated (uninjured). Rats were given alprostadil (0.3 mu g/kg/min, continuous subcutaneous (s.c.) infusion) or vehicle for 1 week after the injury and sacrificed at 4 weeks or 8 weeks. Segments of common carotid arteries corresponding to balloon-injured and uninjured sites were excised and subjected to elastica van Gieson staining. Cross-sectional areas were measured by computed planimetry. Alprostadil prevented intimal-thickening at both 4 and 8 weeks. In addition, alprostadil prevented the increase in intimal area/area surrounded by external elastic lamina at both 4 and 8 weeks. Alprostadil had no effects on body weight, heart rate, or systolic blood pressure. Our study demonstrated that alprostadil administered only for the initial 1 week had long-term (up to 8 weeks) preventive effects on intimal thickening. Alprostadil may be useful to prevent restenosis after balloon angioplasty.

引用

页码：119 / 130

页数：12

共 37 条

[1] LOCAL-DELIVERY OF VASCULAR ENDOTHELIAL GROWTH-FACTOR ACCELERATES REENDOTHELIALIZATION AND ATTENUATES INTIMAL HYPERPLASIA IN BALLOON-INJURED RAT CAROTID-ARTERY [J].