Antibiotic heterogeneity: from concept to practice

被引：34

作者：

Bal, A. M. ^{[1
,2
]}

Kumar, A. ^{[2
]}

Gould, I. M. ^{[2
]}

机构：

[1] Crosshouse Hosp, Dept Med Microbiol, Kilmarnock KA2 0BE, Scotland

[2] Aberdeen Royal Infirm, Dept Med Microbiol, Aberdeen, Scotland

来源：

ANTIMICROBIAL THERAPEUTICS REVIEWS | 2010年 / 1213卷

关键词：

antibiotic cycling; antibiotic mixing; antibiotic diversity; mathematical models; Pseudomonas aeruginosa; Escherichia coli; Klebsiella; MRSA; PAMS; VENTILATOR-ASSOCIATED PNEUMONIA; INTENSIVE-CARE-UNIT; INADEQUATE ANTIMICROBIAL TREATMENT; PSEUDOMONAS-AERUGINOSA; PRESCRIBING PRACTICES; CYCLING PROGRAM; RESISTANCE; ROTATION; IMPACT; INFECTIONS;

D O I：

10.1111/j.1749-6632.2010.05867.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Bacterial resistance to multiple antibiotics is a serious and emerging threat. Several measures have been proposed to curb this growing trend. These include prescribing restrictions, education, and infection control that target transmission, among several others. Antibiotic cycling has been a subject of debate, and although many investigators have studied the utility of antibiotic cycling with the help of theoretical models or as part of clinical investigations, several areas remain undefined and unclear. This review summarizes the available information on antibiotic heterogeneity (antibiotic cycling, antibiotic mixing, and other types of antibiotic protocols) with a critical analysis of the published studies.

引用

页码：81 / 91

页数：11

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