Extreme hyperferritinemia in the pediatric emergency setting: haemophagocytic lymphohistiocytosis, macrophage activation syndrome, sepsis and more

被引：0
|
作者：
Scozzafava, C. [1 ]
Sestito, S. [1 ]
Concolino, D. [1 ]
Giannotta, A. [1 ]
Del Giudice, M. Miraglia [2 ]
Parisi, G. F. [3 ]
Ceravolo, G. [4 ]
Cuppari, C. [4 ]
Pensabene, L. [1 ]
Sutera, D. [1 ]
Spagnuolo, A. [1 ]
Gallizzi, R. [1 ]
机构：
[1] Magna Graecia Univ Catanzaro, Pediat Unit, Dept Sci Hlth, Viale Pio X, I-88100 Catanzaro, Italy
[2] Univ Campania Luigi Vanvitelli, Dept Woman Child & Specialized Surg, Naples, Italy
[3] Univ Catania, Dept Clin & Expt Med, Catania, Italy
[4] Univ Messina, Dept Human Pathol Adult & Dev Age Gaetano Barresi, Unit Emergency Pediat, G Martino Policlin, Messina, Italy
来源：
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS | 2022年 / 36卷 / 01期
关键词：
hyperferritinemia; hemophagocytic lymphohistiocytosis; macrophage activation syndrome; cytokine storm; COVID-19; FERRITIN;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Ferritin plays an important role in modulating inflammation and is a significant marker in some life-threatening pathological conditions. Hemophagocytic lymphohistiocytosis (HLH), macrophage activation syndrome (MAS), sepsis, and the more recent multisystem inflammatory syndrome in children (MIS-C) share many clinical and laboratory aspects, including the increase in ferritin levels, so that they are considered hyperferritinemic syndromes. In the pediatric emergency setting, the finding of high ferritin levels if associated with fever requires considering these rare syndromes to start a timely therapy.
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页码：129 / 133
页数：5
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