One-pot three-component green synthesis of novel dihydrophthalazine-1,4-diones

被引：3

作者：

Suman, M. ^{[1
]}

Vijayabhaskar, B. ^{[2
]}

Kumar, U. K. Syam ^{[3
]}

Rao, B. Venkateswara ^{[4
]}

机构：

[1] Dr Reddys Labs Ltd, API Plant, IDA, Proc Res & Dev, Pydibhimavaram 532409, Ranasthalam Man, India

[2] GVK Bio Sci PVT LTD, Survay Part 125, IDA, Hyderabad 500076, Andhra Pradesh, India

[3] Dr Reddys Labs Ltd, Integrated Prod Dev, Innovat Plaza, Qutubullapur 500072, Andhra Pradesh, India

[4] Andhra Univ, Dept Organ Chem Foods Drugs & Water, Visakhapatnam 530003, Andhra Pradesh, India

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2017年 / 87卷 / 09期

关键词：

green chemistry; phthalic anhydride; benzaldehydes; Meldrum's acid; VIRUS 3C PROTEINASE; ACID; ALDEHYDES; ANALOGS;

D O I：

10.1134/S1070363217090201

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Green and efficient one-pot three-component synthesis of novel 2-(7-amino-2,2-dimethyl-4-oxo-5-phenyl-4,5-dihydropyrano[2,3-d][1,3]dioxin-6-ylcarbonyl)-2,3-dihydrophthalazine-1,4-diones have been developed by condensing 3-(1,4-dioxo-1,2,3,4-tetrahydrophthalazin-2-yl)-3-oxopropanenitrile with benzaldehydes and Meldrum's acid using L-proline as catalyst in ethanol at room temperature. The products have been isolated as pure compounds in good yields without using column chromatography.

引用

页码：2039 / 2044

页数：6

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