Utility of the Parkinson's disease-Cognitive Rating Scale for the screening of global cognitive status in Huntington's disease

被引：17

作者：

Martinez-Horta, Saul ^{[1
,2
,3
,4
,5
]}

Horta-Barba, Andrea ^{[1
,2
,3
,5
]}

Perez-Perez, Jesus ^{[1
,2
,3
,4
,5
]}

Sampedro, Frederic ^{[1
,2
,3
,4
]}

de Lucia, Natascia ^{[5
,6
]}

De Michele, Giuseppe ^{[5
,6
]}

Kehrer, Stefanie ^{[5
,7
]}

Priller, Josef ^{[5
,7
]}

Migliore, Simone ^{[8
]}

Squitieri, Ferdinando ^{[8
]}

Castaldo, Anna ^{[5
,9
]}

Mariotti, Caterina ^{[5
,9
]}

Mananes, Veronica ^{[5
,10
]}

Luis Lopez-Sendon, Jose ^{[5
,10
]}

Rodriguez, Noelia ^{[5
,11
]}

Martinez-Descals, Asuncion ^{[5
,11
]}

Garcia-Ruiz, Pedro ^{[5
,11
]}

Julio, Filipa ^{[5
,12
,13
]}

Januario, Cristina ^{[5
,12
,13
]}

Delussi, Marianna ^{[5
,14
]}

de Tommaso, Marina ^{[5
,14
]}

Noguera, Sandra ^{[5
,15
]}

Ruiz-Idiago, Jesus ^{[5
,15
,18
]}

Sitek, Emilia J. ^{[5
,16
,17
]}

Nuzzi, Angela ^{[5
]}

Pagonabarraga, Javier ^{[1
,2
,3
,4
,5
]}

Kulisevsky, Jaime ^{[1
,2
,3
,4
,5
]}

机构：

[1] Hosp Santa Creu & Sant Pau, Neurol Dept, Movement Disorders Unit, Mas Casanovas 90, Barcelona 08041, Spain

[2] Biomed Res Inst IIB St Pau, Barcelona, Spain

[3] Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid, Spain

[4] Autonomous Univ Barcelona, Barcelona, Spain

[5] EHDN, Ulm, Germany

[6] Univ Naples Federico II, Naples, Italy

[7] Charite, Dept Neuropsychiat, Berlin, Germany

[8] Fdn IRCCS Casa Sollievo Sofferenza Res Hosp, Huntington & Rare Dis Unit, San Giovanni Rotondo, Italy

[9] Fdn IRCCS Ist Neurol Carlo Besta, Milan, Italy

[10] Hosp Univ Ramon & Cajal, Dept Neurol, Madrid, Spain

[11] Fdn Jimenez Diaz, Dept Neurol, Madrid, Spain

[12] Coimbra Univ Hosp, Neurol Dept, Coimbra, Portugal

[13] Univ Coimbra, Coimbra Inst Biomed Imaging & Translat Res CIBIT, Coimbra, Portugal

[14] Bari Aldo Moro Univ, SMBNOS Dept, Bari, Italy

[15] Hosp Mare Deu de la Merce, Barcelona, Spain

[16] Med Univ Gdansk, Fac Hlth Sci, Dept Neurol & Psychiat Nursing, Gdansk, Poland

[17] St Adalbert Hosp, Dept Neurol, Gdansk, Poland

[18] Autonomous Univ Barcelona, Dept Psychiat & Forens Med, Barcelona, Spain

来源：

JOURNAL OF NEUROLOGY | 2020年 / 267卷 / 05期

基金：

英国医学研究理事会;

关键词：

Huntington's disease; Neuropsychology; Cognition; Cognitive assessment; Psychometrics; CLINICAL-TRIALS; TRACK-HD; RELIABILITY; PREMANIFEST; IMPAIRMENT; CRITIQUE; DECLINE;

D O I：

10.1007/s00415-020-09730-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background Cognitive impairment is an essential feature of Huntington's disease (HD) and dementia is a predictable outcome in all patients. However, validated instruments to assess global cognitive performance in the field of HD are lacking. Objectives We aimed to explore the utility of the Parkinson's disease-Cognitive Rating Scale (PD-CRS) for the screening of global cognition in HD. Methods A multicenter cohort of 132 HD patients at different disease stages and 33 matched healthy controls were classified as having preserved cognition, mild cognitive impairment (HD-MCI) or dementia (HD-Dem) according to the Clinical Dementia Rating and Functional Independence Score. The PD-CRS and the Mini-Mental State Examination were administered. Receiver operating characteristic curve analysis was used to determine optimal cutoffs to differentiate patients according to their cognitive status. Results A PD-CRS cutoff score <= 81/82 was optimal to detect HD-MCI (sensitivity = 93%; specificity = 80%; area under the curve (AUC) = 0.940), and <= 63/64 was optimal to detect HD-Dem (sensitivity = 90%; specificity = 87%; AUC = 0.933). MMSE scores failed to show robust psychometric properties in this context. Discussion The PD-CRS is a valid and reliable instrument to assess global cognition in HD in routine clinical care and clinical trials.

引用

页码：1527 / 1535

页数：9

共 32 条

[1] The Addenbrooke's Cognitive Examination-Revised accurately detects cognitive decline in Huntington's disease [J].