Acute Δ9-tetrahydrocannabinol exposure facilitates quinpirole-induced hyperlocomotion

被引：13
作者：
Gorriti, MA
Ferrer, B
del Arco, I
Bermúdez-Silva, FJ
de Diego, Y
Fernandez-Espejo, E
Navarro, M
de Fonseca, FR
机构：
[1] Fdn IMABIS, Hosp Carlos Haya Malaga, Unidad Invest, Malaga 29010, Spain
[2] Univ Complutense Madrid, Fac Psicol, Dept Psicobiol, Inst Univ Drogodependencias, E-28040 Madrid, Spain
[3] Univ Sevilla, Fac Psicol, Dept Fisiol, Seville, Spain
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2005年 / 81卷 / 01期
关键词：
behavior; cannabinoids; CBI receptors; dopamine receptors; locomotion; quinpirole; THC; sensitization;
D O I：
10.1016/j.pbb.2005.02.004
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The endogenous cannabinoid system works as a feedback signal controlling dopamine-induced facilitation of motor behaviors. The present study explored whether a single acute stimulation of CB1 cannabinoid receptors with (-)-Delta(9)-tetrahydrocannabinol (THC, 5 mg kg(-1) i.p.) results in modifications in the sensitivity to the acute behavioral effects of the dopamine D-2/D-3 receptor agonist quinpirole (0.025, 0.25 and 1 mg kg(-1), s.c.) 24 h after THC administration. Cannabinoid pretreatment increased the sensitivity to quinpirole-induced hyperlocomotion 24 h after its administration. The data indicated that THC induced a desensitization of cannabinoid receptors, as revealed by a reduction in CBI receptor-agonist induced GTP-gamma-S incorporation in striatal membranes. These results might be relevant for understanding the effect of cannabinoid exposure in dopamine-related neuropsychiatric disorders. (C) 2005 Elsevier Inc. All rights reserved.
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收藏
页码：71 / 77
页数：7
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