Smed-β-catenin-1 is required for anteroposterior blastema polarity in planarian regeneration

被引：286

作者：

Petersen, Christian P. ^{[1
]}

Reddien, Peter W. ^{[1
,2
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

SCIENCE | 2008年 / 319卷 / 5861期

关键词：

D O I：

10.1126/science.1149943

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Planarian flatworms can regenerate heads at anterior- facing wounds and tails at posterior- facing wounds throughout the body. How this regeneration polarity is specified has been a classic problem for more than a century. We identified a planarian gene, Smed-beta catenin-1, that controls regeneration polarity. Posterior- facing blastemas regenerate a head instead of a tail in Smed-beta catenin- 1( RNAi) animals. Smed-beta catenin- 1 is required after wounding and at any posterior- facing wound for polarity. Additionally, intact Smed-beta catenin- 1( RNAi) animals display anteriorization during tissue turnover. Five Wnt genes and a secreted Frizzled- related Wnt antagonist- like gene are expressed in domains along the anteroposterior axis that reset to new positions during regeneration, which suggests that Wnts control polarity through Smed-beta catenin-1. Our data suggest that beta-catenin specifies the posterior character of the anteroposterior axis throughout the Bilateria and specifies regeneration polarity in planarians.

引用

页码：327 / 330

页数：4

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