Smed-β-catenin-1 is required for anteroposterior blastema polarity in planarian regeneration

被引：280
作者：
Petersen, Christian P. [1 ]
Reddien, Peter W. [1 ,2 ]
机构：
[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
[2] MIT, Dept Biol, Cambridge, MA 02139 USA
来源：
SCIENCE | 2008年 / 319卷 / 5861期
关键词：
D O I：
10.1126/science.1149943
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Planarian flatworms can regenerate heads at anterior- facing wounds and tails at posterior- facing wounds throughout the body. How this regeneration polarity is specified has been a classic problem for more than a century. We identified a planarian gene, Smed-beta catenin-1, that controls regeneration polarity. Posterior- facing blastemas regenerate a head instead of a tail in Smed-beta catenin- 1( RNAi) animals. Smed-beta catenin- 1 is required after wounding and at any posterior- facing wound for polarity. Additionally, intact Smed-beta catenin- 1( RNAi) animals display anteriorization during tissue turnover. Five Wnt genes and a secreted Frizzled- related Wnt antagonist- like gene are expressed in domains along the anteroposterior axis that reset to new positions during regeneration, which suggests that Wnts control polarity through Smed-beta catenin-1. Our data suggest that beta-catenin specifies the posterior character of the anteroposterior axis throughout the Bilateria and specifies regeneration polarity in planarians.
引用
收藏
页码：327 / 330
页数：4
相关论文
共 25 条
  • [1] The new animal phylogeny: Reliability and implications
    Adoutte, A
    Balavoine, G
    Lartillot, N
    Lespinet, O
    Prud'homme, B
    de Rosa, R
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (09) : 4453 - 4456
  • [2] Double-stranded RNA specifically disrupts gene expression during planarian regeneration
    Alvarado, AS
    Newmark, PA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (09) : 5049 - 5054
  • [3] BRONDSTED HV, 1969, PLANARIAN REGENERATI, P276
  • [4] Formation of the head organizer in hydra involves the canonical Wnt pathway
    Broun, M
    Gee, L
    Reinhardt, B
    Bode, HR
    [J]. DEVELOPMENT, 2005, 132 (12): : 2907 - 2916
  • [5] The establishment of Spemann's organizer and patterning of the vertebrate embryo
    De Robertis, EM
    Larraín, J
    Oelgeschläger, M
    Wessely, O
    [J]. NATURE REVIEWS GENETICS, 2000, 1 (03) : 171 - 181
  • [6] Formation and function of Spemann's organizer
    Harland, R
    Gerhart, J
    [J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1997, 13 : 611 - 667
  • [7] A β-catenin identified by functional rather than sequence criteria and its role in Wnt/MAPK signaling
    Kidd, AR
    Miskowski, JA
    Siegfried, KR
    Sawa, H
    Kimble, J
    [J]. CELL, 2005, 121 (05) : 761 - 772
  • [8] Kiecker C, 2001, DEVELOPMENT, V128, P4189
  • [9] Canonical and non,canonical Wnt signaling pathways in Calenorhabditis elgans:: variations on a common signaling theme
    Korswagen, HC
    [J]. BIOESSAYS, 2002, 24 (09) : 801 - 810
  • [10] Unexpected complexity of the Wnt gene family in a sea anemone
    Kusserow, A
    Pang, K
    Sturm, C
    Hrouda, M
    Lentfer, J
    Schmidt, HA
    Technau, U
    von Haeseler, A
    Hobmayer, B
    Martindale, MQ
    Holstein, TW
    [J]. NATURE, 2005, 433 (7022) : 156 - 160
123